About: Cyclin K goes with Cdk12 and Cdk13

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cyclin K goes with Cdk12 and Cdk13 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development. The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development. (en)
Title	Cyclin K goes with Cdk12 and Cdk13 Cyclin K goes with Cdk12 and Cdk13 (en)
skos:prefLabel	Cyclin K goes with Cdk12 and Cdk13 Cyclin K goes with Cdk12 and Cdk13 (en)
skos:notation	RIV/00027162:_____/12:#0000936!RIV13-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(GAP305/11/1564), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kohoutek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	129349
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/12:#0000936
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Transcription; Posttranscriptional processing; DNA damage; P-TEFb; Cyclin L; CTD code; CTD kinase; Phosphorylation of serine 2; BRCA1; ATR; FANCI; FANCD2 (en)
http://linked.open.../riv/klicoveSlovo	Transcription BRCA1 DNA damage CTD kinase P-TEFb CTD code Cyclin L FANCD2 FANCI Phosphorylation of serine 2 Posttranscriptional processing ATR
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3FB2A0562AD0]
http://linked.open...i/riv/nazevZdroje	Cell Division
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology The novel isoform of cyclin K is a partner of cdk12 kinase regulating eukaryotic transcription and alternative splicing
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Blažek, D. Kohoutek, Jiří
http://linked.open...ain/vavai/riv/wos	000303827600001
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	1747-1028
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1747-1028-7-12

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software