About: Genetic basis of resistance to quaternary ammonium compounds

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About: Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although the qac genes are named after one of their main substrates (i.e. quaternary ammonium compounds), these also encode for resistance to a broad spectrum of other cationic compounds such as intercalating dyes, diamidines and biguanides. The various Qac proteins are involved in relatively low specific efflux-based multidrug pumps and belong to a family of small multidrug resistance proteins. Even though the practical significance of qac-mediated resistance lies mainly in resistance to antiseptics, contradictory findings on this topic are still reported. Therefore, the aim of this review was to summarise the current knowledge on the qac-mediated resistance with special emphasise on resistance to antiseptics and its relevance for practice. Although the qac genes are named after one of their main substrates (i.e. quaternary ammonium compounds), these also encode for resistance to a broad spectrum of other cationic compounds such as intercalating dyes, diamidines and biguanides. The various Qac proteins are involved in relatively low specific efflux-based multidrug pumps and belong to a family of small multidrug resistance proteins. Even though the practical significance of qac-mediated resistance lies mainly in resistance to antiseptics, contradictory findings on this topic are still reported. Therefore, the aim of this review was to summarise the current knowledge on the qac-mediated resistance with special emphasise on resistance to antiseptics and its relevance for practice. (en)
Title	Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review (en)
skos:prefLabel	Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review (en)
skos:notation	RIV/00027162:_____/12:#0000913!RIV13-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED0006/01/01), P(QJ1210301), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Jaglič, Zoran Červinková, Dana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	137892
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/12:#0000913
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antimicrobial; disinfectant; biocide; benzalkonium; chlorhexidine; cation; susceptibility (en)
http://linked.open.../riv/klicoveSlovo	antimicrobial cation susceptibility biocide chlorhexidine benzalkonium disinfectant
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[63E7621E8163]
http://linked.open...i/riv/nazevZdroje	Veterinární Medicína
http://linked.open...in/vavai/riv/obor	GM
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Advanced Microbiology & Immunology Research in Veterinary Medicine Research, new products and services to create the centre of mastitis prevention, detection and support of its treatment.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Jaglič, Zoran Červinková, Dana
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0375-8427
number of pages	7 (xsd:int)

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