About: SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression

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About: SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Genes localized at Salmonella pathogenicity island-1 (SPI-1) are involved in Salmonella invasion of host non-professional phagocytes. In addition to invasion, SPI-1-encoded proteins induce cell death of macrophages via activation of caspase-1 which also cleaves proIL-1 beta and proIL-18, precursors of 2 proinflammatory cytokines. We were therefore interested in whether SPI-1-encoded type III secretion system (T3SS) may influence proinflammatory response of macrophages. We infected primary porcine alveolar macrophages with wild-type S. Typhimurium and S. Enteritidis and their SPI-1 deletion mutants. SPI1 mutants of both serovars invaded approx. 5 times less efficiently than the wild-type strains and despite this, macrophages responded to the infection with Delta SPI1 mutants by increased expression of proinflammatory cytokines. Our results showed that the SPI-1-encoded T3SS is required not only for cell invasion but in macrophages also for the suppression of early proinflammatory cytokine expression. Genes localized at Salmonella pathogenicity island-1 (SPI-1) are involved in Salmonella invasion of host non-professional phagocytes. In addition to invasion, SPI-1-encoded proteins induce cell death of macrophages via activation of caspase-1 which also cleaves proIL-1 beta and proIL-18, precursors of 2 proinflammatory cytokines. We were therefore interested in whether SPI-1-encoded type III secretion system (T3SS) may influence proinflammatory response of macrophages. We infected primary porcine alveolar macrophages with wild-type S. Typhimurium and S. Enteritidis and their SPI-1 deletion mutants. SPI1 mutants of both serovars invaded approx. 5 times less efficiently than the wild-type strains and despite this, macrophages responded to the infection with Delta SPI1 mutants by increased expression of proinflammatory cytokines. Our results showed that the SPI-1-encoded T3SS is required not only for cell invasion but in macrophages also for the suppression of early proinflammatory cytokine expression. (en)
Title	SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression (en)
skos:prefLabel	SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression (en)
skos:notation	RIV/00027162:_____/11:#0000751!RIV12-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1B44020), P(ED0006/01/01), P(GA524/08/1606), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	16
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Faldyna, Martin Štěpánová, Hana Matiašovic, Ján Volf, Jiří Pavlová, Barbora Ondráčková, Petra Crhánová, Magdaléna Rychlík, Ivan Karasová, Daniela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	231474
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/11:#0000751
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NITRIC-OXIDE PRODUCTION; SEROVAR TYPHIMURIUM; PATHOGENICITY ISLANDS; SPI-1 GENES; CELL-DEATH; APOPTOSIS; INVASION; SIPB; ENTERITIDIS; CASPASE-1 (en)
http://linked.open.../riv/klicoveSlovo	APOPTOSIS CASPASE-1 CELL-DEATH ENTERITIDIS INVASION NITRIC-OXIDE PRODUCTION PATHOGENICITY ISLANDS SEROVAR TYPHIMURIUM SIPB SPI-1 GENES
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A20432429C61]
http://linked.open...i/riv/nazevZdroje	Veterinary Research
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular immune response to defined deleted mutants of Salmonella in pigs The pathogenesis of enteric colibacillosis and salmonellosis of pigs. Center for Advanced Microbiology & Immunology Research in Veterinary Medicine
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Crhánová, Magdaléna Faldyna, Martin Karasová, Daniela Matiašovic, Ján Pavlová, Barbora Rychlík, Ivan Volf, Jiří Štěpánová, Hana Ondráčková, Petra
http://linked.open...ain/vavai/riv/wos	000290659600005
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0928-4249
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1297-9716-42-16

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