About: Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium

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About: Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We analysed porcine antigen-specific immunity six months after experimental infection with Mycobacterium avium subsp. avium (MAA) by measuring IFN-gamma production (ELISA, qRT-PCR and flow cytometry) and lymphocyte transformation test after in vitro re-stimulation with the MAA-derived antigen. In MAA-infected animals, IFN-gamma was increased at both mRNA and protein levels in response to the specific MAA antigen in the blood, spleen and mesenteric lymph nodes. Similarly, a positive antigen-driven response was detected by proliferation assay. Using flow cytometry, we found double-positive CD4+CD8+ lymphocytes as the major T lymphocyte subset producing IFN-gamma after specific re-stimulation. In conclusion, antigen-specific immune response in swine is retained for at least six months after infection with MAA. Furthermore, we identified the presence of antigen-specific double-positive CD4+CD8+ cells in MAA-infected pigs. We analysed porcine antigen-specific immunity six months after experimental infection with Mycobacterium avium subsp. avium (MAA) by measuring IFN-gamma production (ELISA, qRT-PCR and flow cytometry) and lymphocyte transformation test after in vitro re-stimulation with the MAA-derived antigen. In MAA-infected animals, IFN-gamma was increased at both mRNA and protein levels in response to the specific MAA antigen in the blood, spleen and mesenteric lymph nodes. Similarly, a positive antigen-driven response was detected by proliferation assay. Using flow cytometry, we found double-positive CD4+CD8+ lymphocytes as the major T lymphocyte subset producing IFN-gamma after specific re-stimulation. In conclusion, antigen-specific immune response in swine is retained for at least six months after infection with MAA. Furthermore, we identified the presence of antigen-specific double-positive CD4+CD8+ cells in MAA-infected pigs. (en)
Title	Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium (en)
skos:prefLabel	Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium (en)
skos:notation	RIV/00027162:_____/11:#0000744!RIV12-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1B53009), P(ED0006/01/01), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Faldyna, Martin Štěpánová, Hana Matiašovic, Ján Štromerová, Nikola Pavlová, Barbora Pavlík, Ivo Kaevska, Marija
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	189382
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/11:#0000744
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pig; avian tuberculosis; interferon-gamma; CD4+CD8+ T cell (en)
http://linked.open.../riv/klicoveSlovo	pig CD4+CD8+ T cell avian tuberculosis interferon-gamma
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[EBE78E0575D1]
http://linked.open...i/riv/nazevZdroje	Veterinary Immunology and Immunopathology
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Advanced Microbiology & Immunology Research in Veterinary Medicine Avian tuberculosis and mycobacterioses: the development of methods for theirs prevention and eradication by study of mycobacterial sources and pathogenesis of infection
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	142
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Kaevska, Marija Matiašovic, Ján Pavlík, Ivo Pavlová, Barbora Štromerová, Nikola Štěpánová, Hana
http://linked.open...ain/vavai/riv/wos	000292486400013
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0165-2427
number of pages	6 (xsd:int)

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