About: Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains

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About: Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The facultative intracellular bacterium Francisella tularensis is the causal agent of the serious infectious disease tularemia. Despite intensive research, the pathogenetic mechanisms remain largely unknown. Generally, secreted proteins play an important role in pathogenicity of intracellular microbes. We investigated the protein composition of the culture filtrate proteins of highly virulent F. tularensis subsp. tularensis, strain SCHU S4 and attenuated F. tularensis subsp. holarctica, live vaccine strain using a comparative proteomic analysis. The majority of identified proteins have been implicated in virulence mechanisms of other pathogens, and several have been categorized as having moonlighting properties. Acid phosphatase (precursor) A (AcpA), beta-lactamase, and hypothetical protein FTT0484 were unique for the SCHU S4 strain. AcpA may be of importance for F. tularensis subsp. tularensis virulence due to the recently described AcpA role in the F. tularensis escape from phagosomes. The facultative intracellular bacterium Francisella tularensis is the causal agent of the serious infectious disease tularemia. Despite intensive research, the pathogenetic mechanisms remain largely unknown. Generally, secreted proteins play an important role in pathogenicity of intracellular microbes. We investigated the protein composition of the culture filtrate proteins of highly virulent F. tularensis subsp. tularensis, strain SCHU S4 and attenuated F. tularensis subsp. holarctica, live vaccine strain using a comparative proteomic analysis. The majority of identified proteins have been implicated in virulence mechanisms of other pathogens, and several have been categorized as having moonlighting properties. Acid phosphatase (precursor) A (AcpA), beta-lactamase, and hypothetical protein FTT0484 were unique for the SCHU S4 strain. AcpA may be of importance for F. tularensis subsp. tularensis virulence due to the recently described AcpA role in the F. tularensis escape from phagosomes. (en)
Title	Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains (en)
skos:prefLabel	Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains (en)
skos:notation	RIV/00027162:_____/10:#0000705!RIV11-MZE-00027162
http://linked.open...avai/riv/aktivita	I P V Z
http://linked.open...avai/riv/aktivity	I, P(ME08105), V, Z(MO0FVZ0000501), Z(MO0FVZ0000604)
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Reichelová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	251331
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000705
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Culture filtrate proteins; Francisella tularensis; Microbiology; Moonlighting proteins; Secreted proteins; Virulence factors (en)
http://linked.open.../riv/klicoveSlovo	Francisella tularensis Virulence factors Microbiology Culture filtrate proteins Moonlighting proteins Secreted proteins
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[AF15A9AEF359]
http://linked.open...i/riv/nazevZdroje	Proteomics
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Differential proteome analysis of bacterial Francisella tularensis glyco- and phospho- proteins
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Reichelová, Markéta Konečná, K. Alefantis, T. DelVecchio, V. G. Henrychová, L. Klimentova, J. Lenco, J. Macela, A. Stulík, J.
http://linked.open...ain/vavai/riv/wos	000285882200015
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN Informační zabezpečení krizového managementu pro oblast zdravotnictví
issn	1615-9853
number of pages	12 (xsd:int)

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