About: Reciprocal Translocation t(4;7)(q14;q28) in Cattle: Molecular Characterization

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About: Reciprocal Translocation t(4;7)(q14;q28) in Cattle: Molecular Characterization Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cytogenetic analysis of a phenotypically normal young bull from Marchigiana breed revealed the presence of an abnormal karyotype. The presence of one oversize chromosome in all metaphases, suggested the presence of a reciprocal translocation. RBG-banding and FISH analyses, using several cattle specific BACs, confirmed this hypothesis revealing the presence of a (4;7) reciprocal translocation. In addition the presence of rcp(4;7) was confirmed by FISH experiments using BTA4 end BTA7 whole chromosome probes. Both parents were investigated and they showed a normal karyotype. Moreover we established that the rcp is balanced, as any loss or gain of genetic materials was observed in proximity of BTA4 and BTA7 break points. We performed this analysis using a cattle genome specific CGH array (in this array 244K probes are scattered over all autosomes and X chromosome). To our knowledge this is the first time in which the balanced condition of a cattle rcp is ascertained using a CGH array approach. Cytogenetic analysis of a phenotypically normal young bull from Marchigiana breed revealed the presence of an abnormal karyotype. The presence of one oversize chromosome in all metaphases, suggested the presence of a reciprocal translocation. RBG-banding and FISH analyses, using several cattle specific BACs, confirmed this hypothesis revealing the presence of a (4;7) reciprocal translocation. In addition the presence of rcp(4;7) was confirmed by FISH experiments using BTA4 end BTA7 whole chromosome probes. Both parents were investigated and they showed a normal karyotype. Moreover we established that the rcp is balanced, as any loss or gain of genetic materials was observed in proximity of BTA4 and BTA7 break points. We performed this analysis using a cattle genome specific CGH array (in this array 244K probes are scattered over all autosomes and X chromosome). To our knowledge this is the first time in which the balanced condition of a cattle rcp is ascertained using a CGH array approach. (en)
Title	Reciprocal Translocation t(4;7)(q14;q28) in Cattle: Molecular Characterization Reciprocal Translocation t(4;7)(q14;q28) in Cattle: Molecular Characterization (en)
skos:prefLabel	Reciprocal Translocation t(4;7)(q14;q28) in Cattle: Molecular Characterization Reciprocal Translocation t(4;7)(q14;q28) in Cattle: Molecular Characterization (en)
skos:notation	RIV/00027162:_____/10:#0000682!RIV11-MZE-00027162
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Černohorská, Halina Rubeš, Jiří Kopečná, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	284186
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000682
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cattle; Array-CGH; FISH; Reciprocal translocation (en)
http://linked.open.../riv/klicoveSlovo	Cattle FISH Reciprocal translocation Array-CGH
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[AF96331A2D14]
http://linked.open...i/riv/nazevZdroje	Cytogenetic and Genome Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	129
http://linked.open...iv/tvurceVysledku	Rubeš, Jiří Černohorská, Halina Kopečná, Olga Béna, F. De Lorenzi, L. Gimelli, S. Molteni, L. Parma, P. Zannotti, M.
http://linked.open...ain/vavai/riv/wos	000280683800006
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	1424-8581
number of pages	7 (xsd:int)

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