About: Experimental oral and ocular Encephalitozoon cuniculi infection in rabbits

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to characterize both cell-mediated and antibody response in rabbits after experimental infection with Encephalitozoon cuniculi using two different infection routes: oral and ocular. SPF rabbits were infected with low and high infection doses. Monitored parameters included clinical signs, detection of spores in urine, antibody response detected with ELISA, and cell-mediated immunity detected by antigen-driven lymphocyte proliferation. At week 13 post infection, half of the rabbits in each group were suppressed by intramuscularly administration of dexamethasone. At week 18 post infection, animals were euthanized. Clinical signs were mild with exacerbation after immunosuppression. Spores in urine and antigen-specific cell-mediated immunity were detected from week 5 and 4 post infection, respectively. Specific IgM were detected one week after infection, and IgG antibodies followed one week later in rabbits infected with the high dose. The aim of this study was to characterize both cell-mediated and antibody response in rabbits after experimental infection with Encephalitozoon cuniculi using two different infection routes: oral and ocular. SPF rabbits were infected with low and high infection doses. Monitored parameters included clinical signs, detection of spores in urine, antibody response detected with ELISA, and cell-mediated immunity detected by antigen-driven lymphocyte proliferation. At week 13 post infection, half of the rabbits in each group were suppressed by intramuscularly administration of dexamethasone. At week 18 post infection, animals were euthanized. Clinical signs were mild with exacerbation after immunosuppression. Spores in urine and antigen-specific cell-mediated immunity were detected from week 5 and 4 post infection, respectively. Specific IgM were detected one week after infection, and IgG antibodies followed one week later in rabbits infected with the high dose. (en)
Title	Experimental oral and ocular Encephalitozoon cuniculi infection in rabbits Experimental oral and ocular Encephalitozoon cuniculi infection in rabbits (en)
skos:prefLabel	Experimental oral and ocular Encephalitozoon cuniculi infection in rabbits Experimental oral and ocular Encephalitozoon cuniculi infection in rabbits (en)
skos:notation	RIV/00027162:_____/10:#0000650!RIV11-GA0-00027162
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(ED0006/01/01), P(GP524/08/P568), V, Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Faldyna, Martin Matiašovic, Ján Kovařčík, Kamil Jeklová, Edita Mašková, Jarmila Levá, Lenka Kummer, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	258320
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000650
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	encephalitozoonosis; ocular infection; antibodies; serology; cell immunity (en)
http://linked.open.../riv/klicoveSlovo	cell immunity antibodies serology encephalitozoonosis ocular infection
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1E12016F7CFE]
http://linked.open...i/riv/nazevZdroje	Parasitology
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Advanced Microbiology & Immunology Research in Veterinary Medicine Immune response of rabbits (Oryctolagus cuniculus) to experimental infection with Encephalitozoon cuniculi
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	137
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Levá, Lenka Matiašovic, Ján Škorič, M. Jeklová, Edita Kovařčík, Kamil Kummer, Vladimír Mašková, Jarmila
http://linked.open...ain/vavai/riv/wos	000283794600003
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0031-1820
number of pages	9 (xsd:int)

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