About: Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae

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About: Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present study was aimed at describing porcine mononuclear phagocyte subpopulations infiltrating inflamed tissue of pigs under in vivo conditions. Actinobacillus pleuropneumoniae infection was used to induce an inflammatory response. CD172a, CD14, CD163, MHCII and CD203a cell surface molecules were used to identify mononuclear phagocyte by flow cytometry. Changes in mononuclear phagocyte subpopulations in the peripheral blood and bone marrow compartments along with the analysis of mononuclear phagocyte appearing in the inflamed lungs were assessed to elucidate the possible origin and maturation stages of the infiltrating mononuclear phagocyte. The mononuclear phagocyte population migrating to the inflamed lungs was positive for molecules CD14 and CD163 and positive or negative for molecules CD203a and MHCII. Based on results, two different maturation pathways of mononuclear phagocyte were suggested in pigs. The use of these pathways differs under inflammatory and non-inflammatory conditions. The present study was aimed at describing porcine mononuclear phagocyte subpopulations infiltrating inflamed tissue of pigs under in vivo conditions. Actinobacillus pleuropneumoniae infection was used to induce an inflammatory response. CD172a, CD14, CD163, MHCII and CD203a cell surface molecules were used to identify mononuclear phagocyte by flow cytometry. Changes in mononuclear phagocyte subpopulations in the peripheral blood and bone marrow compartments along with the analysis of mononuclear phagocyte appearing in the inflamed lungs were assessed to elucidate the possible origin and maturation stages of the infiltrating mononuclear phagocyte. The mononuclear phagocyte population migrating to the inflamed lungs was positive for molecules CD14 and CD163 and positive or negative for molecules CD203a and MHCII. Based on results, two different maturation pathways of mononuclear phagocyte were suggested in pigs. The use of these pathways differs under inflammatory and non-inflammatory conditions. (en)
Title	Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae (en)
skos:prefLabel	Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae (en)
skos:notation	RIV/00027162:_____/10:#0000640!RIV11-GA0-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED0006/01/01), P(GPP502/10/P362), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Nechvátalová, Kateřina Faldyna, Martin Ondráčková, Petra Kučerová, Zdeňka Levá, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	279895
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000640
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mononuclear phagocyte; pig; Actinobacillus pleuropneumoniae (en)
http://linked.open.../riv/klicoveSlovo	Actinobacillus pleuropneumoniae pig mononuclear phagocyte
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[2514CAB28A81]
http://linked.open...i/riv/nazevZdroje	Veterinary Research
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional heterogeneity of porcine mononuclear phagocytes during experimentally induced lung inflammation by Actinobacillus pleuropneumoniae Center for Advanced Microbiology & Immunology Research in Veterinary Medicine
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Kučerová, Zdeňka Levá, Lenka Nechvátalová, Kateřina Ondráčková, Petra Dominguez, H.
http://linked.open...ain/vavai/riv/wos	000284063300009
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0928-4249
number of pages	14 (xsd:int)

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