About: alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

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About: alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mitocans are drugs selectively killing cancer cells by destabilizing mitochondria and generate reactive oxygen species (ROS). However, the molecular events by which ROS production leads to apoptosis has not been clearly defined. In this study with the mitocan alpha-tocopheryl succinate (alpha-TOS) the role of the Bcl-2 family proteins in the mechanism of malignant cell apoptosis has been determined. Exposure of several different cancer cell lines to alpha-TOS caused a profound conformational change in the pro-apoptotic protein, Bak, involving oligomerization in all cell types tested. Bak forms high molecular weight complexes in the mitochondria upon alfa-TOS treatment. We conclude that the major events induced by alpha-TOS in cancer cells downstream of ROS production leading to mitochondrial apoptosis involve the Noxa-Bak axis. It is proposed that this represents a common mechanism for mitochondrial destabilization activated by a variety of mitocans that induce accumulation of ROS. Mitocans are drugs selectively killing cancer cells by destabilizing mitochondria and generate reactive oxygen species (ROS). However, the molecular events by which ROS production leads to apoptosis has not been clearly defined. In this study with the mitocan alpha-tocopheryl succinate (alpha-TOS) the role of the Bcl-2 family proteins in the mechanism of malignant cell apoptosis has been determined. Exposure of several different cancer cell lines to alpha-TOS caused a profound conformational change in the pro-apoptotic protein, Bak, involving oligomerization in all cell types tested. Bak forms high molecular weight complexes in the mitochondria upon alfa-TOS treatment. We conclude that the major events induced by alpha-TOS in cancer cells downstream of ROS production leading to mitochondrial apoptosis involve the Noxa-Bak axis. It is proposed that this represents a common mechanism for mitochondrial destabilization activated by a variety of mitocans that induce accumulation of ROS. (en)
Title	alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels (en)
skos:prefLabel	alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels (en)
skos:notation	RIV/00027162:_____/10:#0000624!RIV11-GA0-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP204/09/P632), P(IAA500520602), P(IAA500520702), P(KAN200520703), Z(AV0Z50520701), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Procházka, Lubomír Turánek, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	246012
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000624
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Vitamin E succinate; Apoptosis; Bak; Noxa; Mitochondria; Permeabilization (en)
http://linked.open.../riv/klicoveSlovo	Apoptosis Bak Mitochondria Noxa Permeabilization Vitamin E succinate
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[FBC17D38DF07]
http://linked.open...i/riv/nazevZdroje	Apoptosis
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	The use of ultrasound in nanomedicine Mechanism(s) controlling sensitivity and/or resistance of cancer cell lines to anticancer analogues of vitamin E Nový model indukce apoptozy pomocí %22mitokanů%22 Cell death pathways in mesothelioma cells exposed to pharmacological and immunological inducers of apoptosis: genomic and proteomic approach
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Ralph, S. J. Dong, L. Procházka, Lubomír Turánek, Jaroslav Freeman, R. Neužil, J. Valis, K.
http://linked.open...ain/vavai/riv/wos	000279190700003
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR Animal disease research, prevention and food chain protection
issn	1360-8185
number of pages	13 (xsd:int)

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