About: Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study we were interested in the colonisation and early immune response of Balb/C mice to infection with Salmonella Enteritidis and isogenic pathogenicity island free mutants. The virulence of S. Enteritidis for Balb/C mice was exclusively dependent on intact SPI-2. Infections with any of the mutants harbouring SPI-2 (including the mutant in which we left only SPI-2 but removed SPI-1, SPI-3, SPI-4 and SPI-5) resulted in fatalities, liver injures and NK cell depletion from the spleen and blood. The infection was of minimal influence on counts of splenic CD4 CD8 T lymphocytes and gama delta T-lymphocytes although a reduced ability of splenic lymphocytes to respond to non-specific mitogens indicated general immunosuppression in mice infected with SPI-2 positive S. Enteritidis mutants was observed. The decrease of NK cells in circulation can be used as a marker of attenuation of S. Enteritidis mutants for Balb/C mice. In this study we were interested in the colonisation and early immune response of Balb/C mice to infection with Salmonella Enteritidis and isogenic pathogenicity island free mutants. The virulence of S. Enteritidis for Balb/C mice was exclusively dependent on intact SPI-2. Infections with any of the mutants harbouring SPI-2 (including the mutant in which we left only SPI-2 but removed SPI-1, SPI-3, SPI-4 and SPI-5) resulted in fatalities, liver injures and NK cell depletion from the spleen and blood. The infection was of minimal influence on counts of splenic CD4 CD8 T lymphocytes and gama delta T-lymphocytes although a reduced ability of splenic lymphocytes to respond to non-specific mitogens indicated general immunosuppression in mice infected with SPI-2 positive S. Enteritidis mutants was observed. The decrease of NK cells in circulation can be used as a marker of attenuation of S. Enteritidis mutants for Balb/C mice. (en)
Title	Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis (en)
skos:prefLabel	Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis (en)
skos:notation	RIV/00027162:_____/10:#0000620!RIV11-GA0-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED0006/01/01), P(GA524/09/0215), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	75
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Faldyna, Martin Volf, Jiří Ondráčková, Petra Šebková, Alena Havlíčková, Hana Rychlík, Ivan Šišák, František Kummer, Vladimír Karasová, Daniela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	263887
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/10:#0000620
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pathogenicity island; Salmonella Enteritidis, NK cell; mice (en)
http://linked.open.../riv/klicoveSlovo	NK cell Salmonella Enteritidis pathogenicity island mice
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F905CDEC36DB]
http://linked.open...i/riv/nazevZdroje	BMC Microbiology
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Advanced Microbiology & Immunology Research in Veterinary Medicine Pathogenicity islands and Salmonella virulence for chicken and mice
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Havlíčková, Hana Karasová, Daniela Rychlík, Ivan Volf, Jiří Šišák, František Ondráčková, Petra Kummer, Vladimír Šebková, Alena
http://linked.open...ain/vavai/riv/wos	000276396600001
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	1471-2180
number of pages	11 (xsd:int)

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