About: P-TEFb - the final frontier

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Regulation of gene expression is essential to all aspects of physiological processes in cells. It gives ultimately cells the ability to efficiently respond to extra- and intracellular stimuli participating in cell cycle, growth, differentiation and survival. Regulation of gene expression is executed primarily at the level of transcription of specific mRNAs by RNA polymerase II (RNAPII), typically in several distinct phases. Among them, transcription elongation is positively regulated by the positive transcription elongation factor b (P-TEFb), consisting of CDK9 and cyclin T1, T2 or K. Over the years, we have learned a great deal about molecular composition of P-TEFb complexes and their role in transcription of specific genes, but P-TEFb function in other physiological processes was not apparent until just recently. In light of emerging discoveries connecting P-TEFb to regulation of cell cycle, development and several diseases, I would like to discuss these observations as well as future perspectives. Regulation of gene expression is essential to all aspects of physiological processes in cells. It gives ultimately cells the ability to efficiently respond to extra- and intracellular stimuli participating in cell cycle, growth, differentiation and survival. Regulation of gene expression is executed primarily at the level of transcription of specific mRNAs by RNA polymerase II (RNAPII), typically in several distinct phases. Among them, transcription elongation is positively regulated by the positive transcription elongation factor b (P-TEFb), consisting of CDK9 and cyclin T1, T2 or K. Over the years, we have learned a great deal about molecular composition of P-TEFb complexes and their role in transcription of specific genes, but P-TEFb function in other physiological processes was not apparent until just recently. In light of emerging discoveries connecting P-TEFb to regulation of cell cycle, development and several diseases, I would like to discuss these observations as well as future perspectives. (en)
Title	P-TEFb - the final frontier P-TEFb - the final frontier (en)
skos:prefLabel	P-TEFb - the final frontier P-TEFb - the final frontier (en)
skos:notation	RIV/00027162:_____/09:#0000627!RIV11-GA0-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1832), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kohoutek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	337629
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/09:#0000627
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	P-TEFb; transcription; gene expression; development (en)
http://linked.open.../riv/klicoveSlovo	gene expression development P-TEFb transcription
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B8AEFDF9C966]
http://linked.open...i/riv/nazevZdroje	Cell Division
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Function of Positive Transcription Elongation Factor b (P-TEFb) in cardiac hypertrophy
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Kohoutek, Jiří
http://linked.open...ain/vavai/riv/wos	000283782300001
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	1747-1028
number of pages	15 (xsd:int)

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