About: The mycotoxin deoxynivalenol promotes uptake of Salmonella Typhimurium in porcine macrophages, associated with ERK 1/2 induced cytoskeleton reorganization

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About: The mycotoxin deoxynivalenol promotes uptake of Salmonella Typhimurium in porcine macrophages, associated with ERK 1/2 induced cytoskeleton reorganization Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study aimed at examining the interaction between mycotoxin deoxynivalenol (DON) and Salmonella Typhimurium at the level of the porcine innate immune system, represented by macrophages. First, we assessed the direct cytotoxic effect of DON on porcine macrophages. Incubation with 0.25 ug/ml of DON or higher resulted in a significant cytotoxic effect after 24 h of incubation. Secondly, the direct toxic effect of DON on the growth and on the expression of Salmonella pathogenicity island 1 (SPI-1) and SPI-2 virulence genes of S. Typhimurium was determined. At low non-cytotoxic concentrations, DON was of no effect on growth or virulence gene expression of S. Typhimurium. However, when the invasion and intracellular survival of S. Typhimurium in macrophages preexposed to 0.025 ug/ml of DON was examined, DON significantly promoted the uptake of S. Typhimurium into macrophages which coincided with F-actin reorganization due to the activation of ERK1/2. This study aimed at examining the interaction between mycotoxin deoxynivalenol (DON) and Salmonella Typhimurium at the level of the porcine innate immune system, represented by macrophages. First, we assessed the direct cytotoxic effect of DON on porcine macrophages. Incubation with 0.25 ug/ml of DON or higher resulted in a significant cytotoxic effect after 24 h of incubation. Secondly, the direct toxic effect of DON on the growth and on the expression of Salmonella pathogenicity island 1 (SPI-1) and SPI-2 virulence genes of S. Typhimurium was determined. At low non-cytotoxic concentrations, DON was of no effect on growth or virulence gene expression of S. Typhimurium. However, when the invasion and intracellular survival of S. Typhimurium in macrophages preexposed to 0.025 ug/ml of DON was examined, DON significantly promoted the uptake of S. Typhimurium into macrophages which coincided with F-actin reorganization due to the activation of ERK1/2. (en)
Title	The mycotoxin deoxynivalenol promotes uptake of Salmonella Typhimurium in porcine macrophages, associated with ERK 1/2 induced cytoskeleton reorganization The mycotoxin deoxynivalenol promotes uptake of Salmonella Typhimurium in porcine macrophages, associated with ERK 1/2 induced cytoskeleton reorganization (en)
skos:prefLabel	The mycotoxin deoxynivalenol promotes uptake of Salmonella Typhimurium in porcine macrophages, associated with ERK 1/2 induced cytoskeleton reorganization The mycotoxin deoxynivalenol promotes uptake of Salmonella Typhimurium in porcine macrophages, associated with ERK 1/2 induced cytoskeleton reorganization (en)
skos:notation	RIV/00027162:_____/09:#0000551!RIV10-MZE-00027162
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Rychlík, Ivan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	328159
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/09:#0000551
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	deoxynivalenol; Salmonella Typhimurium; pig; macrophage; cytoskeleton (en)
http://linked.open.../riv/klicoveSlovo	macrophage Salmonella Typhimurium cytoskeleton pig deoxynivalenol
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[5B6EB937EEF4]
http://linked.open...i/riv/nazevZdroje	Veterinary Research
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Rychlík, Ivan Ducatelle, R. Haesebrouck, F. Pasmans, F. Boyen, F. Croubels, S. De Backer, P. Vandenbroucke, V.
http://linked.open...ain/vavai/riv/wos	000272039500013
http://linked.open...n/vavai/riv/zamer	Zdravá zvířata a bezpečné potraviny jako základ pro zdraví lidí
issn	0928-4249
number of pages	12 (xsd:int)

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