About: Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX

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About: Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1 alpha and the partner factor ARNT (AhR nuclear translocator). We have previously observed that HIF-1 alpha competes with the AhR for interaction with ARNT under conditions when both factors are activated. We have therefore investigated whether TCDD-induced activation of the AhR pathway might interfere with CA IX expression. The results from the present study suggest that TCDD treatment reduces hypoxic induction of both CA IX mRNA and protein expression. Moreover, the transcriptional activity of the CA9 promoter was significantly reduced by expression of CAAhR (Constitutively active AhR), which activates, transcription in a ligand-independent manner. Finally, we found that ARNT is critical for both hypoxic induction and the TCDD-mediated inhibition of CA9 expression. Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1 alpha and the partner factor ARNT (AhR nuclear translocator). We have previously observed that HIF-1 alpha competes with the AhR for interaction with ARNT under conditions when both factors are activated. We have therefore investigated whether TCDD-induced activation of the AhR pathway might interfere with CA IX expression. The results from the present study suggest that TCDD treatment reduces hypoxic induction of both CA IX mRNA and protein expression. Moreover, the transcriptional activity of the CA9 promoter was significantly reduced by expression of CAAhR (Constitutively active AhR), which activates, transcription in a ligand-independent manner. Finally, we found that ARNT is critical for both hypoxic induction and the TCDD-mediated inhibition of CA9 expression. (en)
Title	Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX (en)
skos:prefLabel	Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX (en)
skos:notation	RIV/00027162:_____/09:#0000540!RIV10-MZE-00027162
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50040507), Z(AV0Z50040702), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Machala, Miroslav Vondráček, Jan Pěnčíková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	339690
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/09:#0000540
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ARNT TRANSCRIPTION FACTOR; INDUCIBLE FACTOR-I; DIOXIN RECEPTOR; SIGNALING PATHWAYS; GENE-EXPRESSION; AH RECEPTOR; PAS DOMAIN; CROSS-TALK; IDENTIFICATION; PROTEIN (en)
http://linked.open.../riv/klicoveSlovo	PROTEIN IDENTIFICATION GENE-EXPRESSION AH RECEPTOR SIGNALING PATHWAYS ARNT TRANSCRIPTION FACTOR CROSS-TALK DIOXIN RECEPTOR INDUCIBLE FACTOR-I PAS DOMAIN
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DC237072E4E7]
http://linked.open...i/riv/nazevZdroje	Biochemical Journal
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	419
http://linked.open...iv/tvurceVysledku	Vondráček, Jan Machala, Miroslav Pěnčíková, Kateřina Pastorek, J. Kopáček, J. Poellinger, L. Gradin, K. Holotnakova, T. Pastoreková, S. Takáčová, M.
http://linked.open...ain/vavai/riv/wos	000265196900018
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Zdravá zvířata a bezpečné potraviny jako základ pro zdraví lidí
issn	0264-6021
number of pages	7 (xsd:int)

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