About: Cyclin T2 Is Essential for Mouse Embryogenesis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cyclin T2 Is Essential for Mouse Embryogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The positive transcription elongation factor b (P-TEFb) is essential for the elongation of transcription and cotranscriptional processing by RNA polymerase II. In mammals, it contains predominantly cyclin-dependent kinase 9 (Cdk9) and cyclin T1 (CycT1) or CycT2. To determine if these cyclins have redundant functions or affect distinct sets of genes, we genetically inactivated the CycT2 gene (Ccnt2) using the gene trap technology in the mouse. CycT2 was expressed abundantly during embryogenesis, in all adult tissues and organs. However, despite numerous matings of heterozygous mice, we observed no CycT2(-/-) embryos, pups, or adult mice. This early lethality could have resulted from decreased expression of critical genes, which were revealed by short interfering RNAs against CycT2 in embryonic stem cells. Thus, CycT1 and CycT2 are not redundant, and these different P-TEFb complexes regulate subsets of distinct genes that are important for embryonic development. The positive transcription elongation factor b (P-TEFb) is essential for the elongation of transcription and cotranscriptional processing by RNA polymerase II. In mammals, it contains predominantly cyclin-dependent kinase 9 (Cdk9) and cyclin T1 (CycT1) or CycT2. To determine if these cyclins have redundant functions or affect distinct sets of genes, we genetically inactivated the CycT2 gene (Ccnt2) using the gene trap technology in the mouse. CycT2 was expressed abundantly during embryogenesis, in all adult tissues and organs. However, despite numerous matings of heterozygous mice, we observed no CycT2(-/-) embryos, pups, or adult mice. This early lethality could have resulted from decreased expression of critical genes, which were revealed by short interfering RNAs against CycT2 in embryonic stem cells. Thus, CycT1 and CycT2 are not redundant, and these different P-TEFb complexes regulate subsets of distinct genes that are important for embryonic development. (en)
Title	Cyclin T2 Is Essential for Mouse Embryogenesis Cyclin T2 Is Essential for Mouse Embryogenesis (en)
skos:prefLabel	Cyclin T2 Is Essential for Mouse Embryogenesis Cyclin T2 Is Essential for Mouse Embryogenesis (en)
skos:notation	RIV/00027162:_____/09:#0000536!RIV10-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1832), Z(MZE0002716202)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kohoutek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	308776
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/09:#0000536
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transcription; P-TEFb; cyclin T2; cyclin T1; embryogenesis (en)
http://linked.open.../riv/klicoveSlovo	cyclin T1 cyclin T2 P-TEFb transcription embryogenesis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[550C88B1B27E]
http://linked.open...i/riv/nazevZdroje	Molecular and Cellular Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Function of Positive Transcription Elongation Factor b (P-TEFb) in cardiac hypertrophy
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Blažek, D. Kohoutek, Jiří Luo, Z. Jiang, H. Li, Q. Petrlin, M. B.
http://linked.open...ain/vavai/riv/wos	000266436300004
http://linked.open...n/vavai/riv/zamer	Animal disease research, prevention and food chain protection
issn	0270-7306
number of pages	6 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software