About: Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection

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About: Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Salmonella enterica serovars Typhimurium or Enteritidis can colonise liver and spleen in particular hosts while infections with serovars Infantis, Agona, Hadar etc. are usually limited to gastrointestinal tract. Reasons for this behavior are unknown, although it has been shown that sodCI and spv genes exhibit a strict distribution between more and less virulent serovars and they influence Salmonella virulence. In this study we therefore removed these two genes from S. Enteritidis genome and compared the virulence of such a mutant with the virulence of S. Infantis, S. Agona and S. Hadar for chickens and highly sensitive Balb/C mice. Single strain infections showed that the deletion of these two genes from S. Enteritidis resulted in the reduction of its virulence for mice but not for chickens. This indicated that in mice but not in chickens the virulence of sodCI and spv mutant was reduced to the natural virulence of serovars Infantis, Agona and Hadar. Salmonella enterica serovars Typhimurium or Enteritidis can colonise liver and spleen in particular hosts while infections with serovars Infantis, Agona, Hadar etc. are usually limited to gastrointestinal tract. Reasons for this behavior are unknown, although it has been shown that sodCI and spv genes exhibit a strict distribution between more and less virulent serovars and they influence Salmonella virulence. In this study we therefore removed these two genes from S. Enteritidis genome and compared the virulence of such a mutant with the virulence of S. Infantis, S. Agona and S. Hadar for chickens and highly sensitive Balb/C mice. Single strain infections showed that the deletion of these two genes from S. Enteritidis resulted in the reduction of its virulence for mice but not for chickens. This indicated that in mice but not in chickens the virulence of sodCI and spv mutant was reduced to the natural virulence of serovars Infantis, Agona and Hadar. (en)
Title	Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection (en)
skos:prefLabel	Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection Deletion of sodCI and spvBC in Salmonella e enterica serovar Enteritidis reduced its virulence to the natural virulence of serovar Agona, Hadar and Infantis for mice but not for chickens early after infection (en)
skos:notation	RIV/00027162:_____/09:#0000510!RIV10-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06030), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika	3-4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Havlíčková, Hana Rychlík, Ivan Šišák, František Karasová, Daniela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	309360
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/09:#0000510
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Salmonella; sodCI; spvB; virulence; chicken; mouse (en)
http://linked.open.../riv/klicoveSlovo	Salmonella sodCI spvB virulence chicken mouse
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[72602B2A483E]
http://linked.open...i/riv/nazevZdroje	Veterinary Microbiology
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	139
http://linked.open...iv/tvurceVysledku	Havlíčková, Hana Karasová, Daniela Rychlík, Ivan Šišák, František
http://linked.open...ain/vavai/riv/wos	000271775700013
http://linked.open...n/vavai/riv/zamer	Zdravá zvířata a bezpečné potraviny jako základ pro zdraví lidí
issn	0378-1135
number of pages	7 (xsd:int)

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