About: Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene

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About: Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus. The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus. (en)
Title	Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene (en)
skos:prefLabel	Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene (en)
skos:notation	RIV/00027162:_____/09:#0000486!RIV10-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA525/05/2695), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Faldyna, Martin Matiašovic, Ján Mašková, Jarmila Kummer, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	327471
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/09:#0000486
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	polcyclic aromatic hydrocarbons; estrogen receptor; immunohistochemistry; rat uterotrophic bioassay (en)
http://linked.open.../riv/klicoveSlovo	immunohistochemistry estrogen receptor polcyclic aromatic hydrocarbons rat uterotrophic bioassay
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[3973EFF02004]
http://linked.open...i/riv/nazevZdroje	Environmental Toxicology and Pharmacology
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of neonatal exposure to polycyclic aromatic hydrocarbons on the reproductive and immune systém
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Faldyna, Martin Matiašovic, Ján Kummer, Vladimír Mašková, Jarmila
http://linked.open...ain/vavai/riv/wos	000264387200014
http://linked.open...n/vavai/riv/zamer	Zdravá zvířata a bezpečné potraviny jako základ pro zdraví lidí
issn	1382-6689
number of pages	6 (xsd:int)

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