About: Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In previous work, we found significant associations of horse chromosome 15 microsatellite markers HMSO1 and HTG06 with two horse infections, Rhodococcus equi and Lawsonia intracellularis, respectively. Interleukin-1 beta subunit and interleukin-1 receptor antagonist encoding genes (IL1B and IL1RN) could be considered as candidate genes. Therefore, we identified single nucleotide polymorphisms (SNPs) within three interleukin-1 beta functionally related genes: IL1B, IL1RN and Casp1 (interleukin-1 beta converting enzyme/caspasel encoding gene). Using appropriate restriction fragment length polymorphism (PCR-RFLP) and/or single strand conformation polymorphism (PCR-SSCP) markers, their associations with the two infections by genotyping foals from the original study were tested. A statistically significant association between an intronic SNP of the Casp1 gene with R. equi infection was found. The IL1RN gene was physically localized by fluorescence in-situ hybridization to 15q13-q14. In previous work, we found significant associations of horse chromosome 15 microsatellite markers HMSO1 and HTG06 with two horse infections, Rhodococcus equi and Lawsonia intracellularis, respectively. Interleukin-1 beta subunit and interleukin-1 receptor antagonist encoding genes (IL1B and IL1RN) could be considered as candidate genes. Therefore, we identified single nucleotide polymorphisms (SNPs) within three interleukin-1 beta functionally related genes: IL1B, IL1RN and Casp1 (interleukin-1 beta converting enzyme/caspasel encoding gene). Using appropriate restriction fragment length polymorphism (PCR-RFLP) and/or single strand conformation polymorphism (PCR-SSCP) markers, their associations with the two infections by genotyping foals from the original study were tested. A statistically significant association between an intronic SNP of the Casp1 gene with R. equi infection was found. The IL1RN gene was physically localized by fluorescence in-situ hybridization to 15q13-q14. (en)
Title	Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse (en)
skos:prefLabel	Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse Single Nucleotide Polymorphisms of Interleukin-1 beta Related Genes and their Associations with Infection in the Horse (en)
skos:notation	RIV/00027162:_____/08:#0000599!RIV10-MZE-00027162
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA523/06/1402), Z(MZE0002716201)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Matiašovic, Ján Rubeš, Jiří Kubíčková, Svatava Musilová, Petra
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav veterinárního lékařství, v.v.i.
http://linked.open...dnocenehoVysledku	394965
http://linked.open...ai/riv/idVysledku	RIV/00027162:_____/08:#0000599
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	horse; interleukin 1 beta; interleukin 1 receptor antagonist; interleukin 1 beta converting enzyme; polymorphism; infection (en)
http://linked.open.../riv/klicoveSlovo	infection polymorphism horse interleukin 1 beta interleukin 1 beta converting enzyme interleukin 1 receptor antagonist
http://linked.open...ontrolniKodProRIV	[C6E82B19FDA8]
http://linked.open...i/riv/mistoVydani	Basel, Switzerland
http://linked.open...vEdiceCisloSvazku	Developments in Biologicals, vol. 132
http://linked.open...i/riv/nazevZdroje	Animal Genomics for Animal Health
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...v/pocetStranKnihy	440 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunity-related genes in Equids: genetic diversity and comparative genomics
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Kubíčková, Svatava Matiašovic, Ján Rubeš, Jiří Musilová, Petra Hořín, P. Osičková, J. Vyskočil, M. Hubertová, D. Nečesánková, M.
http://linked.open...n/vavai/riv/zamer	Zdravá zvířata a bezpečné potraviny jako základ pro zdraví lidí
number of pages	5 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Karger
https://schema.org/isbn	978-3-8055-8619-1

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