| Attributes | Values |
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| rdf:type
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| Description
| - Je známo, že polychlorované bifenyly (PCB) působí řadou nepříznivých efektů na lidské zdraví, ale jejich vliv na estrogenové signálování není ještě plně objasněn. V této studii byly stanoveny estrogenní/antiestrogenní vlastnosti běžně rozšířených PCB a směsí PCB, které byly izolovány ze séra mužů z vysoce kontaminovaných oblastí východního Slovenska. Bylo zjištěno, že nížechlorované PCB byly estrogenní, zatímco výšechlorované PCB 138, 153, 170, 180, 187, 194, 199, 203 a jejich metabolity byly antiestrogenní. Vysoká hladina PCB ve vzorcích mužských sér souvisela s poklesem estrogenové aktivity a nárůstem dioxinové aktivity. (cs)
- Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lowerchlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as antiestrogens. 17 beta-Estradiol (E2) was responsible for a major part of estrogenic activity identified in total serum extracts.
- Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lowerchlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as antiestrogens. 17 beta-Estradiol (E2) was responsible for a major part of estrogenic activity identified in total serum extracts. (en)
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| Title
| - Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia
- Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia (en)
- Estrogenní, antiestrogenní a dioxinové aktivity ve vzorcích lidských mužských sér z východního Slovenska (cs)
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| skos:prefLabel
| - Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia
- Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia (en)
- Estrogenní, antiestrogenní a dioxinové aktivity ve vzorcích lidských mužských sér z východního Slovenska (cs)
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| skos:notation
| - RIV/00027162:_____/08:#0000471!RIV09-MZE-00027162
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/08:#0000471
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - polychlorinated biphenyls; dioxin-like activity (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - PCBs Human and Environmental Disposition and Toxicology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...v/pocetStranKnihy
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Vondráček, Jan
- Machala, Miroslav
- Plíšková, Martina
- Neča, Jiří
- Trnovec, T.
- Carton, R.
- Kočan, A.
- Petrík, J.
- Sanderson, T.
- Van den Berg, M.
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| |
| https://schema.org/isbn
| |
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