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  • Nitrofuran antibiotics, employed for the treatment of bacterial diseases in livestock production, were banned from use in the European Union (EU) in 1995 due to concerns about the carcinogenicity of their residues in edible tissue. This review provides an overview of nitrofuran toxicity, metabolism, and also specific aspects of legislation surrounding their prohibition. Special attention is devoted to semicarbazide - a nitrofuran metabolite and food contaminant. Analytical procedures for nitrofuran analysis in various matrices and validation requirements for screening and confirmation methods with respect to EU regulations are also reviewed.
  • Nitrofuran antibiotics, employed for the treatment of bacterial diseases in livestock production, were banned from use in the European Union (EU) in 1995 due to concerns about the carcinogenicity of their residues in edible tissue. This review provides an overview of nitrofuran toxicity, metabolism, and also specific aspects of legislation surrounding their prohibition. Special attention is devoted to semicarbazide - a nitrofuran metabolite and food contaminant. Analytical procedures for nitrofuran analysis in various matrices and validation requirements for screening and confirmation methods with respect to EU regulations are also reviewed. (en)
  • Nitrofuranová antibiotika: Přehled o jejich aplikaci, zákazu a analýze residuí. Nitrofuranová antibiotika, používaná k léčení bakteriálních nemocí hospodářských zvířat, byla zákazána k použití v Evropské unii (EU) v roce 1995 vzhledem ke kancerogenitě těchto residuí v poživatelných tkáních.Tento přehled poskytuje obecný pohled na toxicitu nitrofuranů, jejich metabolismus a také na specifické aspekty spojené s jejich zákazem. Zvláštní pozornost je věnována semikarbazidu, který je nitrofuranovým metabolitem nitrofurazonu. Analytické postupy pro analýzu nitrofuranů v různých matricích a validace požadavků pro screeningové a konfirmační metody podle směrnic EU jsou také zpřehledněny. (cs)
Title
  • Nitrofuran antibiotics: a review on the application, prohibition and residual analysis
  • Nitrofuranová antibiotika: přehled o jejich aplikaci, zákazu a analýze residuí (cs)
  • Nitrofuran antibiotics: a review on the application, prohibition and residual analysis (en)
skos:prefLabel
  • Nitrofuran antibiotics: a review on the application, prohibition and residual analysis
  • Nitrofuranová antibiotika: přehled o jejich aplikaci, zákazu a analýze residuí (cs)
  • Nitrofuran antibiotics: a review on the application, prohibition and residual analysis (en)
skos:notation
  • RIV/00027162:_____/08:#0000456!RIV09-MZE-00027162
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1B53020), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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  • 382767
http://linked.open...ai/riv/idVysledku
  • RIV/00027162:_____/08:#0000456
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; IN-HOUSE VALIDATION; TISSUE-BOUND METABOLITE; SOLID-PHASE EXTRACTION; ANTIBODY-BASED ELISA (en)
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  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [19AD9739D55D]
http://linked.open...i/riv/nazevZdroje
  • Veterinární medicína
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 53
http://linked.open...iv/tvurceVysledku
  • Hruška, Karel
  • Fránek, Milan
  • Vass, Maria
http://linked.open...ain/vavai/riv/wos
  • 000260425700002
http://linked.open...n/vavai/riv/zamer
issn
  • 0375-8427
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