| Attributes | Values |
|---|
| rdf:type
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| Description
| - Metylované chryseny (MeChry) jsou významnou složkou cigaretového kouře a navíc 5-MeChry je veden v seznamu možných lidských karcinogenů. Všech šest studovaných MeChry bylo relativně účinnými aktivátory aryl hydrokarbonového receptoru (AhR) a uvolňovalo buňky z kontaktní inhibice. Pouze 5- a 6-MeChry narušovaly mezibuněčnou komunikaci mezerovými spoji, což je další parametr korelující s tumor-promočními schopnostmi xenobiotic. Nadto, pouze 5-MeChry tvořil významné množství DNA aduktů, což korespondovalo s vysokou akumulací buněk v S-fázi buněčného cyklu. (cs)
- Methylated chrysenes (MeChry) are important cigarette smoke constituents and 5-MeChry has been listed as possibly carcinogenic to humans.We examined both genotoxic and nongenotoxic effects of MeChry, using rat liver cell lines as experimental models. All six MeChry were relatively efficient aryl hydrocarbon receptor (AhR) agonists and they disrupted contact inhibition in rat liver epithelial WB-F344 cells. In contrast, only 5- and 6-MeChry were found to acutely inhibit gap junctional intercellular communication (GJIC), another parameter correlating with tumor promoting effects of xenobiotics. However, only 5-MeChry, and not 6-MeChry, induced significant formation of DNA adducts in rat liver epithelial cells, which corresponded with its ability to induce high accumulation of cells in S-phase. All MeChry showed a potency to disrupt cell proliferation control, while 5-MeChry was a single compound inducing DNA damage, disruption of cell cycle control and inhibition of GJIC in rat liver cells.
- Methylated chrysenes (MeChry) are important cigarette smoke constituents and 5-MeChry has been listed as possibly carcinogenic to humans.We examined both genotoxic and nongenotoxic effects of MeChry, using rat liver cell lines as experimental models. All six MeChry were relatively efficient aryl hydrocarbon receptor (AhR) agonists and they disrupted contact inhibition in rat liver epithelial WB-F344 cells. In contrast, only 5- and 6-MeChry were found to acutely inhibit gap junctional intercellular communication (GJIC), another parameter correlating with tumor promoting effects of xenobiotics. However, only 5-MeChry, and not 6-MeChry, induced significant formation of DNA adducts in rat liver epithelial cells, which corresponded with its ability to induce high accumulation of cells in S-phase. All MeChry showed a potency to disrupt cell proliferation control, while 5-MeChry was a single compound inducing DNA damage, disruption of cell cycle control and inhibition of GJIC in rat liver cells. (en)
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| Title
| - Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells
- Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells (en)
- Vlivy metylovaných chrysenů na AhR-dependentní a -independentní toxické děje v krysích jaterních epiteliálních buňkách (cs)
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| skos:prefLabel
| - Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells
- Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells (en)
- Vlivy metylovaných chrysenů na AhR-dependentní a -independentní toxické děje v krysích jaterních epiteliálních buňkách (cs)
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| skos:notation
| - RIV/00027162:_____/08:#0000455!RIV09-MZE-00027162
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA524/05/0595), Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703), Z(MZE0002716201)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/08:#0000455
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Polycyclic aromatic-hydrocarbons; stem-like cells; cancer-risk assessment; cytochrome-P450 enzymes; metabolic-activation; carcinogenic potency; WB-F344 cells (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Nováková, Z.
- Vondráček, Jan
- Machala, Miroslav
- Topinka, J.
- Pěnčíková, Kateřina
- Krčmář, Pavel
- Milcová, A.
- Kozubík, A.
- Švihálková-Šindler, Lenka
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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