| Attributes | Values |
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| rdf:type
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| Description
| - Monomethylated benz[a]anthracenes (MeBaAs) are an important group of methylated derivatives of polycyclic aromatic hydrocarbons (PAHs). Although the methyl substitution reportedly affects their mutagenicity and tumor-initiating activity, little is known about the impact of methylation on the effects associated with activation of the aryl hydrocarbon receptor (AhR)-dependent gene expression and/or toxic events associated with tumor promotion. In the present study, we studied the effects of a series of MeBaAs on the above-mentioned end points in rat liver cell lines and compared them with the effects of benz[a]anthracene (BaA) and the potent carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Methyl substitution enhanced the AhR-mediated activity of BaA derivatives and cell proliferation in contact-inhibited WB-F344 cells. 1-, 2-, 8-, 10-, 11-, and 12-MeBaA inhibited gap junctional intercellular communication (GJIC) in WB-F344 cells. MeBaAs induced low DNA adduct formation.
- Monomethylated benz[a]anthracenes (MeBaAs) are an important group of methylated derivatives of polycyclic aromatic hydrocarbons (PAHs). Although the methyl substitution reportedly affects their mutagenicity and tumor-initiating activity, little is known about the impact of methylation on the effects associated with activation of the aryl hydrocarbon receptor (AhR)-dependent gene expression and/or toxic events associated with tumor promotion. In the present study, we studied the effects of a series of MeBaAs on the above-mentioned end points in rat liver cell lines and compared them with the effects of benz[a]anthracene (BaA) and the potent carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Methyl substitution enhanced the AhR-mediated activity of BaA derivatives and cell proliferation in contact-inhibited WB-F344 cells. 1-, 2-, 8-, 10-, 11-, and 12-MeBaA inhibited gap junctional intercellular communication (GJIC) in WB-F344 cells. MeBaAs induced low DNA adduct formation. (en)
- Monometylované benz[a]antraceny (MeBaA) jsou důležitou skupinou mezi metylovanými polycyklickými aromatickými uhlovodíky. Přestože vliv metylace na mutagenitu a tumorovou iniciaci je znám, my jsme v této studii na krysích potkaních buňkách sledovali, jak metylace ovlivňuje efekty spojené s aktivací aryl-hadrokarbonového receptoru (AhR), jako změny genové exprese a/nebo děje související s tumorovou promocí ve srovnání s benz[a]antracenem (BaA) a známým silným karcinogenm 7,12-dimethylbenz[a]antracenem (DMBA). Naše výsledky ukazují, že metylace zesiluje AhR-dependentní účinky BaA derivátů a zvyšuje buněčnou proliferaci v kontaktně inhibovaných buňkách.1-,2-,8-,10-,11- a 12-MeBeA inhibovali mezibuněčnou komunikaci mezerovými spoji. Všechny MeBaA navozovali malou tvorbu DNA aduktů. (cs)
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| Title
| - Toxic effects of methylated benz[a]anthracenes in liver cells
- Toxické efekty metylovaných benz[a]antracenů v jaterních buňkách (cs)
- Toxic effects of methylated benz[a]anthracenes in liver cells (en)
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| skos:prefLabel
| - Toxic effects of methylated benz[a]anthracenes in liver cells
- Toxické efekty metylovaných benz[a]antracenů v jaterních buňkách (cs)
- Toxic effects of methylated benz[a]anthracenes in liver cells (en)
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| skos:notation
| - RIV/00027162:_____/08:#0000454!RIV09-MZE-00027162
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390703), Z(MZE0002716201)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/08:#0000454
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - JUNCTIONAL INTERCELLULAR COMMUNICATION; STEM-LIKE CELLS; EPITHELIAL-CELLS; METABOLIC-ACTIVATION; DNA-ADDUCTS; CARCINOGENIC POTENCY; NONGENOTOXIC EVENTS; WB-F344 CELLS; AH RECEPTOR (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Chemical Research in Toxicology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Nováková, Z.
- Vondráček, Jan
- Machala, Miroslav
- Topinka, J.
- Pěnčíková, Kateřina
- Krčmář, Pavel
- Marvanová, Soňa
- Milcová, A.
- Trilecová, Lenka
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
| |
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