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| Description
| - As the chronic inflammation is known to contribute to carcinogenesis, we investigated interactions of a major proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), and benzo[a]pyrene (BaP) in regulation of the expression of CYP1A1/1B1 and induction of DNA damage in rat liver epithelial WB-F344 cells. TNF-alpha enhanced induction of CYP1B1, while it simultaneously suppressed the BaP-induced CYP1A1 expression. The observed deregulation of CYP1 induction was found to be associated with a significantly enhanced formation of DNA adducts. The elevated DNA damage corresponded with increased phosphorylation of p53 tumor suppressor at Ser-15 residue, enhanced accumulation of cells in the S-phase of cell cycle and potentiation of BaP-induced apoptosis. Our results seem to indicate that inflammatory conditions might enhance genotoxic effects of carcinogenic polycyclic aromatic hydrocarbons through upregulation of CYP1B1 expression.
- As the chronic inflammation is known to contribute to carcinogenesis, we investigated interactions of a major proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), and benzo[a]pyrene (BaP) in regulation of the expression of CYP1A1/1B1 and induction of DNA damage in rat liver epithelial WB-F344 cells. TNF-alpha enhanced induction of CYP1B1, while it simultaneously suppressed the BaP-induced CYP1A1 expression. The observed deregulation of CYP1 induction was found to be associated with a significantly enhanced formation of DNA adducts. The elevated DNA damage corresponded with increased phosphorylation of p53 tumor suppressor at Ser-15 residue, enhanced accumulation of cells in the S-phase of cell cycle and potentiation of BaP-induced apoptosis. Our results seem to indicate that inflammatory conditions might enhance genotoxic effects of carcinogenic polycyclic aromatic hydrocarbons through upregulation of CYP1B1 expression. (en)
- Vzhledem k tomu, že chronický zánět přispívá ke karcinogenezi, studovali jsme interakci hlavního prozánětlivého cytokinu TNF-alfa a benzo[a]pyrenu (BaP) na indukci exprese CYP1A1/1B1 a poškození DNA. TNF-alfa zvyšoval indukci CYP1B1 a současně snižoval BaP-navozenou expresi CYP1A1. Tato deregulace CYP1 indukce měla souvislost se zvýšenou tvorbou DNA aduktů, která korespondovala se zvýšenou fosforylací tumorového supresora p53 na Ser15, s větším množstvím buněk v S-fázi buněčného cyklu a se zvýšením BaP-navozené apoptózy. (cs)
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| Title
| - Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression
- Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression (en)
- TNF-alfa zesiloval genotoxický účinek benzo[a]pyrenu v krysích jaterních epiteliálních buňkách pomocí zvýšené expresi cytochromu P4501B1 (cs)
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| skos:prefLabel
| - Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression
- Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression (en)
- TNF-alfa zesiloval genotoxický účinek benzo[a]pyrenu v krysích jaterních epiteliálních buňkách pomocí zvýšené expresi cytochromu P4501B1 (cs)
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| skos:notation
| - RIV/00027162:_____/08:#0000452!RIV09-MZE-00027162
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA524/05/0595), Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703), Z(MZE0002716201)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/08:#0000452
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - TNF-alpha; BaP; CYP1B1; liver progenitor cells; AhR; DNA adducts (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Mutat Res.- Fundam. Mol. Mechan. Mutagen.
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Nováková, Z.
- Umannová, Lenka
- Vondráček, Jan
- Machala, Miroslav
- Topinka, J.
- Milcová, A.
- Kozubík, A.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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