About: Expression of macrophage CD14 receptor in the course of experimental inflammatory responses induced by lipopolysaccharide and muramyl dipeptide     Goto   Sponge   NotDistinct   Permalink

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  • The aim of this study was to determine whether expression of CD14 on macrophages is regulated differently during initiation and resolution of the inflammatory response caused by CD14-dependent (lipopolysaccharide - LPS) and CD14-independent (muramyldipeptide - MDP) bacterial signals. Intramammary instillation of MDP and LPS resulted in a significant increase in the total count of CD14+ macrophages after 24 hours in contrast to phosphate buffered saline. During resolution of the inflammatory response, a gradual decrease in the total count of CD14+ macrophages was observed. We therefore assume that the expression of CD14 on macrophages is not regulated differently during the inflammatory responses caused by CD14-dependent and CD14-independent bacterial signals. On the other hand, the stage of the inflammatory response to muramyldipeptide and lipopolysaccharide played an important role in the regulation of CD14 expression on macrophages.
  • The aim of this study was to determine whether expression of CD14 on macrophages is regulated differently during initiation and resolution of the inflammatory response caused by CD14-dependent (lipopolysaccharide - LPS) and CD14-independent (muramyldipeptide - MDP) bacterial signals. Intramammary instillation of MDP and LPS resulted in a significant increase in the total count of CD14+ macrophages after 24 hours in contrast to phosphate buffered saline. During resolution of the inflammatory response, a gradual decrease in the total count of CD14+ macrophages was observed. We therefore assume that the expression of CD14 on macrophages is not regulated differently during the inflammatory responses caused by CD14-dependent and CD14-independent bacterial signals. On the other hand, the stage of the inflammatory response to muramyldipeptide and lipopolysaccharide played an important role in the regulation of CD14 expression on macrophages. (en)
  • Cílem práce bylo determinovat, zda je exprese CD14 na makrofázích rozdílně regulována během iniciace a rezoluce zánětlivé reakce způsobené bakteriálními signály závislými (lipopolysachrid - LPS) a nezávislými (muramyl dipeptid - MDP) na CD14. Intramammární aplikace MDP a LPS vedla ke zvýšení celkového počtu CD14+ makrofágů po 24 hodinách v kontrastu ke kontrole - PBS. Během rezolucezánětlivé reakce byl zaznamenán pokles celkového počtu CD14+ makrofágů. Z toho důvodu předpokládáme, že exprese CD14 není rozdílně regulována během zánětlivé reakce indukované na CD14 závislým či nezávislým činitelem. Na druhé straně, stádium zánětlivé odpovědi hraje významnou roli v regulaci exprese CD14 receptoru na makrofázích. (cs)
Title
  • Expression of macrophage CD14 receptor in the course of experimental inflammatory responses induced by lipopolysaccharide and muramyl dipeptide
  • Expression of macrophage CD14 receptor in the course of experimental inflammatory responses induced by lipopolysaccharide and muramyl dipeptide (en)
  • Exprese receptoru CD14 na makrofágu během experimentální zánětlivé reakce indukované lipopolysacharidem a muramyl dipeptidem (cs)
skos:prefLabel
  • Expression of macrophage CD14 receptor in the course of experimental inflammatory responses induced by lipopolysaccharide and muramyl dipeptide
  • Expression of macrophage CD14 receptor in the course of experimental inflammatory responses induced by lipopolysaccharide and muramyl dipeptide (en)
  • Exprese receptoru CD14 na makrofágu během experimentální zánětlivé reakce indukované lipopolysacharidem a muramyl dipeptidem (cs)
skos:notation
  • RIV/00027162:_____/08:#0000389!RIV09-MZE-00027162
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 367427
http://linked.open...ai/riv/idVysledku
  • RIV/00027162:_____/08:#0000389
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • mammary gland; macrophages; CD14; muramyldipeptide; lipopolysaccharide (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [6BEFE61DA261]
http://linked.open...i/riv/nazevZdroje
  • Veterinární medicína
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 53
http://linked.open...iv/tvurceVysledku
  • Ryšánek, Dušan
  • Sládek, Zbyšek
http://linked.open...ain/vavai/riv/wos
  • 000258374200001
http://linked.open...n/vavai/riv/zamer
issn
  • 0375-8427
number of pages
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