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| Description
| - The study: estrogenic/antiestrogenic effects of benzo(a)pyrene (BaP), benz(a)anthracene (BaA), fluoranthene (Fla) and benzo(k)fluoranthene (BkF), using the immature rat uterotrophic assay. The results suggest that BaA, BaP and Fla behaved as estrogen-like compounds, when applied at 10 mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ER alpha, which was downregulated following the treatment with PAHs, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA induced a significant estrogenic effect already at the dose of 0.1 mg/kg/day. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed. The PAHs under study did not induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining PAHs increased CYP1-dependent monooxygenation activities in liver.
- The study: estrogenic/antiestrogenic effects of benzo(a)pyrene (BaP), benz(a)anthracene (BaA), fluoranthene (Fla) and benzo(k)fluoranthene (BkF), using the immature rat uterotrophic assay. The results suggest that BaA, BaP and Fla behaved as estrogen-like compounds, when applied at 10 mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ER alpha, which was downregulated following the treatment with PAHs, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA induced a significant estrogenic effect already at the dose of 0.1 mg/kg/day. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed. The PAHs under study did not induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining PAHs increased CYP1-dependent monooxygenation activities in liver. (en)
- Cíl studie: prošetřit potenciální estrogenní/antiestrogenní účinky benzo(a)pyrenu (BaP), benz(a)antracenu (BaA), fluorantenu (Fla) and benzo(k)fluorantenu (BkF) použitím uterotrofní bioassay u immaturních potkanů. Výsledky nasvědčují tomu, že při aplikaci 10 mg/kg/den vykazovaly BaA, BaP a Fla slabou estrogenní aktivitu, což potvrdil signifikantní nárůst váhy dělohy a hypertrofie luminálního epitelu. Tento efekt byl zprostředkován via ER alfa a byl blokován simultánní aplikací ER antagonisty ICI 182,780. Aplikace těchto PAHs vedla ke snížení exprese ER v děloze. BaA indukoval průkazný estrogenní účinek již od dávky 0.1 mg/kg. Antiestrogenita BkF, patřícího mezi AhR agonisty nebyla potvrzena. Studované PAHs nevyvolaly v děložní tkáni zřejmé genotoxické poškození, o čemž svědčila slabá úroveň barvení Ser-15-fosforylace protein p53. S výjimkou Fla všechny zbývající PAHs zvyšovaly CYP1-dependentní aktivitu monooxygenace v játrech. (cs)
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| Title
| - Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats
- Estrogenní aktivita polycyklických aromatických uhlovodíků v děloze immaturních Wistar potkanů (cs)
- Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats (en)
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| skos:prefLabel
| - Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats
- Estrogenní aktivita polycyklických aromatických uhlovodíků v děloze immaturních Wistar potkanů (cs)
- Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats (en)
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| skos:notation
| - RIV/00027162:_____/08:#0000359!RIV09-MZE-00027162
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA525/05/2695), Z(AV0Z50040507), Z(AV0Z50040702), Z(MZE0002716201)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/08:#0000359
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - polycyclic aromatic hydrocarbons; rat immature uterotrophic assay; estrogen receptor; cytochrome P450; estradiol metabolism; p53 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Vondráček, Jan
- Zralý, Zdeněk
- Machala, Miroslav
- Kummer, Vladimír
- Mašková, Jarmila
- Neča, Jiří
- Polášková, Pavlína
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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