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| rdf:type
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| Description
| - Salmonella enterica subsp. enterica pocházející z drůbeže se podílí na většině střevních infekcí lidí v Evropě. Proto se stále hledají způsoby, jak v chovech drůbeže snížit její výskyt. Jednou z těchto možností je vakcinace. V této práci jsme porovnali 4 různé inaktivované vakcíny obohacené o SPI-1 a SPI-2 proteiny, které jsou klíčové pro virulenci S. Typhimurium. Kuřata ve věku 6 týdnů byla intramuskulárně vakcinována, revakcinována v 9 týdnech a infikována ve věku 12 týdnů. Dva týdny po infekci bylo sledováno vylučování trusem. Všechny porovnávané inaktivované vakcíny snížily vylučování trusem 10-100x, ale nezjistili jsme žádné rozdíly v účinnosti jednotlivých vakcín. Úroveň ochrany drůbeže těmito inaktivovanými vakcínami však byla výrazně nižší než ochrana po vakcinaci založená na vakcinaci živým kmenem oslabeným mutacemi v genech phoP a rpoS. (cs)
- Salmonella enterica subsp. enterica originating from poultry is responsible for vast majority of human gastrointestinal disorders in Europe. This is why different measures how to decrease its incidence in poultry including vaccination are still being tested. In this study we compared 4 different inactivated vaccines of S. Typhimurium in chicken which were enriched by SPI-1 or SPI-2 proteins that are central to Salmonella virulence. Six-week-old chicken were intramuscularly vaccinated, revaccinated at 9 weeks and challenged at 12 weeks of age. For 2 weeks post challenge the feacal shedding was monitored. There was no significant difference in performance of the 4 compared inactivated vaccines and all of them decreased faecal shedding during the first weeks post infection by 10-1000x when compared with non-immunized control chickens. However the level of protection induced by inactivated vaccines was much lower when compared with the live vaccine based on phoP rpoS double deletion S. Typhimurium mutant.
- Salmonella enterica subsp. enterica originating from poultry is responsible for vast majority of human gastrointestinal disorders in Europe. This is why different measures how to decrease its incidence in poultry including vaccination are still being tested. In this study we compared 4 different inactivated vaccines of S. Typhimurium in chicken which were enriched by SPI-1 or SPI-2 proteins that are central to Salmonella virulence. Six-week-old chicken were intramuscularly vaccinated, revaccinated at 9 weeks and challenged at 12 weeks of age. For 2 weeks post challenge the feacal shedding was monitored. There was no significant difference in performance of the 4 compared inactivated vaccines and all of them decreased faecal shedding during the first weeks post infection by 10-1000x when compared with non-immunized control chickens. However the level of protection induced by inactivated vaccines was much lower when compared with the live vaccine based on phoP rpoS double deletion S. Typhimurium mutant. (en)
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| Title
| - Comparison of live and inactivated Salmonella Typhimurium vaccines containing different combination of SPI-1 and SPI-2 antigens in poultry
- Comparison of live and inactivated Salmonella Typhimurium vaccines containing different combination of SPI-1 and SPI-2 antigens in poultry (en)
- Porovnání živých a inaktivovaných vakcín obsahující různé antigeny na ochranu drůbeže před Salmonella Typhimurium (cs)
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| skos:prefLabel
| - Comparison of live and inactivated Salmonella Typhimurium vaccines containing different combination of SPI-1 and SPI-2 antigens in poultry
- Comparison of live and inactivated Salmonella Typhimurium vaccines containing different combination of SPI-1 and SPI-2 antigens in poultry (en)
- Porovnání živých a inaktivovaných vakcín obsahující různé antigeny na ochranu drůbeže před Salmonella Typhimurium (cs)
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| skos:notation
| - RIV/00027162:_____/08:#0000327!RIV09-MZE-00027162
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(LC06030), Z(MZE0002716201)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/08:#0000327
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Salmonella; live and inactivated vaccine; poultry; phoP; rpoS (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Faldyna, Martin
- Havlíčková, Hana
- Rychlík, Ivan
- Šišák, František
- Kummer, Vladimír
- Papežová, Kateřina
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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