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| Description
| - We examined the immune state of dogs with deep pyoderma to elucidate the relationship between clinical symptoms and immunological processes. We measured selected immunological parameters in control dogs (n = 10) and dogs of various breeds (German Shepherds were not included) affected by deep pyoderma (n = 25). We found that the affected dogs had increased relative counts of neutrophils, decreased relative and absolute counts of lymphocytes, higher relative counts of CD3+ lymphocytes and CD8+ lymphocytes but lower relative counts of CD21+ lymphocytes and CD4+ lymphocytes. The affected dogs exhibited a reduced activity of nonstimulated as well as mitogen-stimulated lymphocytes. Lower values of circulating immune complexes in affected dogs were conditioned by the young age of animals. Nevertheless, the changes found in our study were not expressed in all animals.
- We examined the immune state of dogs with deep pyoderma to elucidate the relationship between clinical symptoms and immunological processes. We measured selected immunological parameters in control dogs (n = 10) and dogs of various breeds (German Shepherds were not included) affected by deep pyoderma (n = 25). We found that the affected dogs had increased relative counts of neutrophils, decreased relative and absolute counts of lymphocytes, higher relative counts of CD3+ lymphocytes and CD8+ lymphocytes but lower relative counts of CD21+ lymphocytes and CD4+ lymphocytes. The affected dogs exhibited a reduced activity of nonstimulated as well as mitogen-stimulated lymphocytes. Lower values of circulating immune complexes in affected dogs were conditioned by the young age of animals. Nevertheless, the changes found in our study were not expressed in all animals. (en)
- Studie byla zaměřena na psy s idiopatickou hlubokou pyodermií. Bylo sledováno 35 psů různých plemen jiných než němečtí ovčáci, z toho 25 psů s klinickými příznaky hluboké pyodermie a 10 klinicky zdravých psů jako kontroly. Bylo provedeno vyšetření vybraných imunologických ukazatelů před zahájením léčby. Psi s pyodermií vykazovali signifikantní snížení lymfocytů a relativní zvýšení neutrofilů. Průtokovou cytometrií bylo zjištěno signifikantní zvýšení relativního zastoupení CD3+ T-lymfocytů a to subpopulace CD8+ lymfocytů a snížení relativního počtu CD21+ B-lymfocytů. Signifikantní snížení relativního počtu CD4+ lymfocytů bylo zjištěno pouze u psů s hlubokou pyodermií, kteří byli léčeni glukokortikoidy. Hodnoty nestimulovaných lymfocytů v testu blastické transformace u nemocných psů vykazovaly sníženou aktivitu a sníženou odpověď lymfocytů in vitro na stimulaci mitogeny. Rozdíly v hodnotách CIK mezi skupinami byly závislé na věku zvířat. (cs)
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| Title
| - Immunological Indicators in Dogs Affected by Deep Pyoderma
- Immunological Indicators in Dogs Affected by Deep Pyoderma (en)
- Úroveň imunologických ukazatelů u psů s hlubokou pyodermií (cs)
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| skos:prefLabel
| - Immunological Indicators in Dogs Affected by Deep Pyoderma
- Immunological Indicators in Dogs Affected by Deep Pyoderma (en)
- Úroveň imunologických ukazatelů u psů s hlubokou pyodermií (cs)
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| skos:notation
| - RIV/00027162:_____/07:#0000255!RIV08-MZE-00027162
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/07:#0000255
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Canine; Skin; Lymphocyte subsets; Lymphocyte activity; Immunocomplexes (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Faldyna, Martin
- Svoboda, M.
- Toman, Miroslav
- Špruček, F.
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| http://linked.open...n/vavai/riv/zamer
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| number of pages
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