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| Description
| - We have characterised postnatal changes in T lymphocyte subsets, especially gamma delta (gd) T lymphocytes, in blood, spleen and lymph nodes. Detection was carried out using two-colour flow cytometry and three-colour immunohistochemistry. During ontogeny, there was a significant increase in the total percentage of gd T cells in the spleen and blood. In the lymph nodes, there were no age-dependent changes in the total percentage of gd T cells, but the percentage of the gd TCR+CD8+ subpopulation significantly increased. The tissue distribution of gd TCR+CD8+ and gd TCR+CD8- cells in the lymph nodes is random and not collocated with a particular area of the organ. Furthermore, postnatal development was characterised by an increasing frequency of CD8+CD3+CD4-gdTCR-, which was compensated by a decreasing proportion of CD4+ lymphocytes. Double positive CD4+CD8+ lymphocytes were rare during the first month of life and a significant age-dependent increase of these cells was found in all the compartments.
- We have characterised postnatal changes in T lymphocyte subsets, especially gamma delta (gd) T lymphocytes, in blood, spleen and lymph nodes. Detection was carried out using two-colour flow cytometry and three-colour immunohistochemistry. During ontogeny, there was a significant increase in the total percentage of gd T cells in the spleen and blood. In the lymph nodes, there were no age-dependent changes in the total percentage of gd T cells, but the percentage of the gd TCR+CD8+ subpopulation significantly increased. The tissue distribution of gd TCR+CD8+ and gd TCR+CD8- cells in the lymph nodes is random and not collocated with a particular area of the organ. Furthermore, postnatal development was characterised by an increasing frequency of CD8+CD3+CD4-gdTCR-, which was compensated by a decreasing proportion of CD4+ lymphocytes. Double positive CD4+CD8+ lymphocytes were rare during the first month of life and a significant age-dependent increase of these cells was found in all the compartments. (en)
- Cílem této studie bylo charakterizovat změny v zastoupení populací T lymfocytů, a zvláště gama delta (gd) T lymfocytů, v časném postnatálním období života selat. Buňky krve, sleziny a mízních uzlin byly charakterizovány pomocí dvoubarevné průtokové cytometrie a trojbarevné imunohistochemie. Byl zaznamenán signifikantní vzestup zastoupení gd T lymfocytů ve slezině a krvi. V mízních uzlinách nebyly zaznamenány změny v zastoupení gd T lymfocytů, ale výrazně stoupal počet jedné populace těchto buněk - gd TCR+CD8+. Tkáňová distribuce gd TCR+CD8+ a gd TCR+CD8- buněk v mízní uzlině byla náhodná a nebyla vázaná na nějakou oblast orgánu. Dále byl postnatální vývoj charakterizován zvyšující se frekvencí CD8+CD3+CD4-gd TCR- buněk, která byla kompenzována klesajícím zastoupením CD4+ lymfocytů. Dvojitě pozitivní CD4+CD8+ lymfocyty byly vzácné v průběhu prvního měsíce života a signifikantní na věku-závislé zvýšení počtu těchto buněk bylo zaznamenáno ve všech sledovaných tkáních. (cs)
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| Title
| - Early postnatal development of the immune system of piglets: The redistribution of T lymphocyte subsets
- Raný postnatální vývoj imunitního systému selat: Redistribuce podskupin T lymfocytů (cs)
- Early postnatal development of the immune system of piglets: The redistribution of T lymphocyte subsets (en)
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| skos:prefLabel
| - Early postnatal development of the immune system of piglets: The redistribution of T lymphocyte subsets
- Raný postnatální vývoj imunitního systému selat: Redistribuce podskupin T lymfocytů (cs)
- Early postnatal development of the immune system of piglets: The redistribution of T lymphocyte subsets (en)
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| skos:notation
| - RIV/00027162:_____/07:#0000222!RIV08-MZE-00027162
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1B44024), Z(MZE0002716201)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/07:#0000222
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Pig; Ontogeny; Flow cytometry; Immunohistochemistry (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Faldyna, Martin
- Levá, Lenka
- Štěpánová, Hana
- Šinkora, J.
- Šamánková, Petra
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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