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| Description
| - Johne's disease (JD), caused by M.a.paratuberculosis, represents a problem in farmed ruminants. A little is known of the JD infection dynamics or immunological response in deer. In this study, typing of MAP isolates from intestinal lymphatic tissues from 74 infected animals showed that clinical isolates of MAP from New Zealand farmed red deer were exclusively of the bovine strain genotype. The susceptibility of deer to MAP was further investigated by experimental oral-route infection studies using defined isolates of virulent bovine and ovine MAP strains. Oral inoculation with high or medium doses of the bovine strain of MAP established 100% infection rates, compared to 69% infection following inoculation with a medium dose of the ovine strain. The high susceptibility of deer to the bovine strain of MAP was confirmed by a 50% infection rate following experimental inoculation with a low dose of bacteria. This study is the 1st report experimental MAP infection in red deer.
- Johne's disease (JD), caused by M.a.paratuberculosis, represents a problem in farmed ruminants. A little is known of the JD infection dynamics or immunological response in deer. In this study, typing of MAP isolates from intestinal lymphatic tissues from 74 infected animals showed that clinical isolates of MAP from New Zealand farmed red deer were exclusively of the bovine strain genotype. The susceptibility of deer to MAP was further investigated by experimental oral-route infection studies using defined isolates of virulent bovine and ovine MAP strains. Oral inoculation with high or medium doses of the bovine strain of MAP established 100% infection rates, compared to 69% infection following inoculation with a medium dose of the ovine strain. The high susceptibility of deer to the bovine strain of MAP was confirmed by a 50% infection rate following experimental inoculation with a low dose of bacteria. This study is the 1st report experimental MAP infection in red deer. (en)
- Johneova choroba (JD), vyvolaná M.a.paratuberculosis, představuje vážný problém u farmově chovaných zvířat. Zatím je toho poměrně málo popsáno o dynamice a imunologické odpovědi jelenů trpících JD infekcí. Tato studie prokázala typizací MAP izolátů ze střevních mízních uzlin ze 74 infikovaných zvířat, že klinické MAP izoláty z Nového Zélandu farmově chovaných jelenů měly exkluzivně bovinní genotyp. Citlivost jelenů k MAP byla detailněji vyšetřována experimentálně orální infekcí použitím definovaných izolátů virulentního bovinního a ovčího MAP kmene. Orální inokuace vysokou nebo střední dávkou bovinního kmene MAP prokázala 100% infekčnost ve srovnání s 69% vyvolání infekce následované po inokulaci se střední dávkou ovčího kmene. Vysoká citlivost jelenů k bovinnímu kmenu MAP byla konfirmována 50% infekčností následovanou po experimentální inokulaci s nízkou dávnou bakterií. Tato studie je první zprávou o experimentální MAP infekci jelenů. (cs)
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| Title
| - Immunological and molecular characterization of susceptibility in relationship to bacterial strain differences in Mycobacterium avium subsp. paratuberculosis infection in the red deer (Cervus elaphus)
- Immunological and molecular characterization of susceptibility in relationship to bacterial strain differences in Mycobacterium avium subsp. paratuberculosis infection in the red deer (Cervus elaphus) (en)
- Imunologická a molekulární charakteristika rozdílné citlivosti bakteriálních kmenů Mycobacterium avium subsp. paratuberculosis ve vyvolání infekce u jelenů (Cervus elaphus) (cs)
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| skos:prefLabel
| - Immunological and molecular characterization of susceptibility in relationship to bacterial strain differences in Mycobacterium avium subsp. paratuberculosis infection in the red deer (Cervus elaphus)
- Immunological and molecular characterization of susceptibility in relationship to bacterial strain differences in Mycobacterium avium subsp. paratuberculosis infection in the red deer (Cervus elaphus) (en)
- Imunologická a molekulární charakteristika rozdílné citlivosti bakteriálních kmenů Mycobacterium avium subsp. paratuberculosis ve vyvolání infekce u jelenů (Cervus elaphus) (cs)
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| skos:notation
| - RIV/00027162:_____/06:#0000120!RIV07-MZE-00027162
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/06:#0000120
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Paratuberculosis, Johne's disease, Mycobacterium avium subsp. paratuberculosis, red deer (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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