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  • We synthesized a series of partially fluorinated pyridinium bromide surfactants. Based on an initial in vitro toxicity assessment, the toxicity of the partially fluorinated pyridinium surfactants was slightly lower or comparable to benzalkonium chloride, a typically cationic surfactant (with IC50s of tested compounds ranging from 5 to 15 uM). An increase in the length and/or the degree of fluorination of the hydrophobic tail correlated with a mild decrease of cytotoxicity and haemolytic activity. Partially fluorinated pyridinium surfactants may, therefore, be useful for biomedical applications such as components for novel gene and drug delivery systems.
  • We synthesized a series of partially fluorinated pyridinium bromide surfactants. Based on an initial in vitro toxicity assessment, the toxicity of the partially fluorinated pyridinium surfactants was slightly lower or comparable to benzalkonium chloride, a typically cationic surfactant (with IC50s of tested compounds ranging from 5 to 15 uM). An increase in the length and/or the degree of fluorination of the hydrophobic tail correlated with a mild decrease of cytotoxicity and haemolytic activity. Partially fluorinated pyridinium surfactants may, therefore, be useful for biomedical applications such as components for novel gene and drug delivery systems. (en)
  • Syntetizovali jsme sérii částečně fluorovaných pyridinium bromid povrchově aktivních látek. Podle hodnocení počáteční toxicity in vitro, byla toxicita částečně fluorovaných pyridinium surfaktantů poněkud nižší nebo srovnatelná s benzalkonium chloridem, typickou kationtovou povrchově aktivní látkou (s IC50s testovaných sloučenin v rozsahu 5 až 15 uM). Zvýšení délky nebo stupně fluorace hydrofóbního okraje bylo v korelaci s mírným poklesem cytotoxicity a hemolytické aktivity. Proto mohou být částečně fluorované pyridiniové surfaktanty užitečné pro aplikaci v biomedicíně jako součásti nových genových a lékových doručovacích (drug delivery) systémů. (cs)
Title
  • Synthesis and Biocompatibility Evaluation of Partially Fluorinated Pyridinium Bromides
  • Hodnocení syntézy a biokompatibility u částečně fluorovaných pyridinium bromidů (cs)
  • Synthesis and Biocompatibility Evaluation of Partially Fluorinated Pyridinium Bromides (en)
skos:prefLabel
  • Synthesis and Biocompatibility Evaluation of Partially Fluorinated Pyridinium Bromides
  • Hodnocení syntézy a biokompatibility u částečně fluorovaných pyridinium bromidů (cs)
  • Synthesis and Biocompatibility Evaluation of Partially Fluorinated Pyridinium Bromides (en)
skos:notation
  • RIV/00027162:_____/06:#0000076!RIV07-MZE-00027162
http://linked.open.../vavai/riv/strany
  • 6
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(QF3115), Z(MZE0002716201)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 502771
http://linked.open...ai/riv/idVysledku
  • RIV/00027162:_____/06:#0000076
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cationic surfactants, partially fluorinated pyridinium surfactants, cytotoxicity, haemolysis, fluorinated cationic surfactants, benzalkonium chloride (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [4561BF677F9D]
http://linked.open...i/riv/nazevZdroje
  • New Journal of Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Turánek, Jaroslav
http://linked.open...n/vavai/riv/zamer
issn
  • 1144-0546
number of pages
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