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| Description
| - In our study, we characterized lymphocyte subsets and activity in peripheral blood (PB), spleen, mesenteric and popliteal lymph nodes in pups from birth till the age of one month and compared the results with the group of three adult dogs. In neonatalpups, lower numbers of CD3+ T-cells were detected in both the spleen and PB than in lymph nodes. In contrast to the other compartments, CD21+ B-cells prevailed in the spleen. Low numbers of CD8+ lymphocytes were characteristic in all compartmentsimmediatelyafter birth. Postnatal development was characterized by an increasing frequency of CD8+ lymphocytes in all organs. Another feature of the early period of life was a relative decrease of B-cell, particularly in the PB and spleen. Stimulationindices uponmitogen-induced proliferation increased proportionally to the age. Based on our exper. data, we have concluded that pups are born with a relatively competent immune system the structure of which markedly develops during a few postnatal weeks
- In our study, we characterized lymphocyte subsets and activity in peripheral blood (PB), spleen, mesenteric and popliteal lymph nodes in pups from birth till the age of one month and compared the results with the group of three adult dogs. In neonatalpups, lower numbers of CD3+ T-cells were detected in both the spleen and PB than in lymph nodes. In contrast to the other compartments, CD21+ B-cells prevailed in the spleen. Low numbers of CD8+ lymphocytes were characteristic in all compartmentsimmediatelyafter birth. Postnatal development was characterized by an increasing frequency of CD8+ lymphocytes in all organs. Another feature of the early period of life was a relative decrease of B-cell, particularly in the PB and spleen. Stimulationindices uponmitogen-induced proliferation increased proportionally to the age. Based on our exper. data, we have concluded that pups are born with a relatively competent immune system the structure of which markedly develops during a few postnatal weeks (en)
- Cílem studie bylo charakterizovat subpopulace lymfocytů a jejich aktivitu v periferní krvi, slezině, mezenteriální a popliteální mízní uzlině u štěňat od narození do věku jednoho měsíce a srovnat je s výsledky získanými u dospělých psů. U novorozenýchštěňat bylo v krvi a slezině detekováno nižší množství CD3+ T-lymfocytů než v mízních uzlinách. Naopak, ve slezině bylo detekováno nejvyšší množství CD21+ B-lymfocytů. Malé množství CD8+ lymfocytů bylo charakteristické pro všechny studované orgánybezprostředně po narození. Další postnatální vývoj byl charakterizován zvyšující se frekvencí CD8+ lymfocytů ve všech studovaných orgánech. Dalším znakem vývoje byl relativní pokles B-lymfocytů zejména ve slezině a krvi. Stimulační indexy v testuproliferace lymfocytů po její indukci mitogeny stoupaly s věkem. Ze studie plyne, že štěňata se rodí s relativně kompetentním imunitním systémem, ale jeho struktura prodělává ještě změny v průběhu několika týdnů po narození. (cs)
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| Title
| - Lymphatic organ development in dogs: major lymphocyte subsets and activity
- Vývoj lymfatických orgánů u psa: hlavní populace a aktivita lymfocytů (cs)
- Lymphatic organ development in dogs: major lymphocyte subsets and activity (en)
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| skos:prefLabel
| - Lymphatic organ development in dogs: major lymphocyte subsets and activity
- Vývoj lymfatických orgánů u psa: hlavní populace a aktivita lymfocytů (cs)
- Lymphatic organ development in dogs: major lymphocyte subsets and activity (en)
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| skos:notation
| - RIV/00027162:_____/05:06000044!RIV06-MZE-00027162
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA524/00/0474), P(GP524/02/P010), Z(MZE0002716201)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/05:06000044
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Canine; Development; Lymphocyte subsets; Flow cytometry; Proliferation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Veterinary Immunology and Immunopathology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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