| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Při kolonizaci střevního traktu je salmonela vystavena nízkému pH v žaludku, detergentní aktivitě žlučových kyselin, snižujícím se dostupnosti kyslíku, četný metabolitů kompetitivní mikroflóry a nakonec i antimikrobiálním peptidům produkovanýmhostitelem.Čtyři hlavní systémy jsou klíčové pro odpověď salmonel na stres, jmenovitě RpoS, PhoPQ, Fur a OmpR/EnvZ. S výjimkou Fur, inaktivace všech ostatních systémů vede ke snížení virulence a takoví mutanti mohou být využiti při konstrukciatenuovaných vakcín. Naproti tome regulační systémy kontrolující odpověd na snižující se koncentraci kyslíku (Fnr a ArcAB) nebo odolnost proti kyslíkovým radikálům (OxyR a SoxRS) nejsou pro plnou virulenci salmonel nezbytné. (cs)
- During intestinal colonisation Salmonella is successively exposed to acid pH in the stomach, to the detergent-like activity of bile, to decreasing oxygen supply, to the presence of multiple metabolites produced by the normal gut microflora and finally itis exposed to cationic antimicrobial peptides present on the surface of epithelial cells. There are four major regulators controlling relevant stress responses in Salmonella, namely RpoS, PhoPQ, Fur and OmpR/EnvZ. Except for Fur, inactivation of genesencoding the other stress regulators results in attenuated virulence and such mutants can therefore be considered as vaccine candidates. In contrast, a decrease in oxygen supply monitored by Fnr and ArcAB, or oxidative stress controlled by OxyR and SoxRSisnot regarded as a stress associated with host colonisation since inactivation of either of these systems does not result in reductions in colonisation.
- During intestinal colonisation Salmonella is successively exposed to acid pH in the stomach, to the detergent-like activity of bile, to decreasing oxygen supply, to the presence of multiple metabolites produced by the normal gut microflora and finally itis exposed to cationic antimicrobial peptides present on the surface of epithelial cells. There are four major regulators controlling relevant stress responses in Salmonella, namely RpoS, PhoPQ, Fur and OmpR/EnvZ. Except for Fur, inactivation of genesencoding the other stress regulators results in attenuated virulence and such mutants can therefore be considered as vaccine candidates. In contrast, a decrease in oxygen supply monitored by Fnr and ArcAB, or oxidative stress controlled by OxyR and SoxRSisnot regarded as a stress associated with host colonisation since inactivation of either of these systems does not result in reductions in colonisation. (en)
|
| Title
| - Salmonella stress management and its relevance to behaviour during intestinal colonization and infection
- Salmonella stress management and its relevance to behaviour during intestinal colonization and infection (en)
- Odolnost salmonel vůči stresu a jeho význam pro kolonizaci střevního traku a infekci (cs)
|
| skos:prefLabel
| - Salmonella stress management and its relevance to behaviour during intestinal colonization and infection
- Salmonella stress management and its relevance to behaviour during intestinal colonization and infection (en)
- Odolnost salmonel vůči stresu a jeho význam pro kolonizaci střevního traku a infekci (cs)
|
| skos:notation
| - RIV/00027162:_____/05:06000024!RIV06-MZE-00027162
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/05:06000024
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - salmonella; acid resistance; bile; cationic antimicrobial peptide; heat shock; virulence; quorum sensing; short chain fatty acid (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - FEMS Microbiology Reviews
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)