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| rdf:type
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| Description
| - V této práci byli připraveni mutanti Salmonella Typhimurium a Enteritidis s delecemi v genech phoP a rpoS, buď samostatně anebo v kombinaci s delecí genu ompC. Tyto kmeny byly testovány na míru jejich atenuace a schopnost inhibice růstu izogenního divokého kmene při experimentální infekci kuřat. Mutant s delecí pouze v genu rpoS inhiboval růst divokého kmene ale jeho virulence nebyla výrazně snížena. Mutanti s delecí v genu phoP, buď samostatně nebo v kombinaci s rpoS, měli výrazně sníženou virulenci a zachovanou schopnost kolonizovat střevní trakt a inhibovat růst divokého kmene. Mutanti s dodatečnou mutací v genu ompC měli sníženou schopnost kolonizovat střevní trakt a rovněž i sníženou schopnost inhibovat růst divokého kmene. (cs)
- In this study, mutants of Salmonella Typhimurium and Enteritidis with deletions in phoP and rpoS, either alone or in combination with ompC, were tested for their level of attenuation and their ability to inhibit the intestinal colonisation of the isogenic parent strains in chickens. Mutants with deletions only in rpoS demonstrated an unaffected potential to inhibit the intestinal colonisation of the challenge strain but were still fully virulent for the chickens. Mutants with deletions in phoP, either alone or in combination with rpoS, resulted in a high level of attenuation, unimpaired ability to colonise the gut and a nearly unaffected potential to inhibit the challenge strain from caecal colonisation. Mutants with an additional deletion in ompC revealed a reduced capacity of intestinal colonisation-inhibition when compared to the control strains and both the single rpoS and the phoP deletion mutants.
- In this study, mutants of Salmonella Typhimurium and Enteritidis with deletions in phoP and rpoS, either alone or in combination with ompC, were tested for their level of attenuation and their ability to inhibit the intestinal colonisation of the isogenic parent strains in chickens. Mutants with deletions only in rpoS demonstrated an unaffected potential to inhibit the intestinal colonisation of the challenge strain but were still fully virulent for the chickens. Mutants with deletions in phoP, either alone or in combination with rpoS, resulted in a high level of attenuation, unimpaired ability to colonise the gut and a nearly unaffected potential to inhibit the challenge strain from caecal colonisation. Mutants with an additional deletion in ompC revealed a reduced capacity of intestinal colonisation-inhibition when compared to the control strains and both the single rpoS and the phoP deletion mutants. (en)
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| Title
| - Intestinal colonisation-inhibition and virulence of Salmonella phoP, rpoS and ompC deletion mutants in chickens
- Intestinal colonisation-inhibition and virulence of Salmonella phoP, rpoS and ompC deletion mutants in chickens (en)
- Inhibice růstu a virulence mutantů salmonel v genech phoP, rpoS a ompC pro kuřata (cs)
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| skos:prefLabel
| - Intestinal colonisation-inhibition and virulence of Salmonella phoP, rpoS and ompC deletion mutants in chickens
- Intestinal colonisation-inhibition and virulence of Salmonella phoP, rpoS and ompC deletion mutants in chickens (en)
- Inhibice růstu a virulence mutantů salmonel v genech phoP, rpoS a ompC pro kuřata (cs)
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| skos:notation
| - RIV/00027162:_____/04:#0000146!RIV08-MZE-00027162
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/04:#0000146
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Salmonella; phoP mutant; Colonisation inhibition; Live vaccine; Chicken (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Rychlík, Ivan
- Methner, U.
- Barrow, P.
- Karasová - Gregorová, Daniela
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| issn
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| number of pages
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