About: Inhibitors of arachidonic acid metabolism potentiate tumor necrosis factor-alfa-induced apoptosis in HL-60 cells     Goto   Sponge   NotDistinct   Permalink

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  • Effect of various modulators of arachidonic acid metabolism and their influence on apoptosis induced by tumor necrosis factor alfa were investigated in human myeloid leukaemia HL-60. Indomethacin and nordihydroguaiaretic acid synergistically potentiated TNF-a induced apoptosis. Our data raise the possibility that indomethacin could potentially be used to improve the treatment of human myeloid leukaemia.
  • Effect of various modulators of arachidonic acid metabolism and their influence on apoptosis induced by tumor necrosis factor alfa were investigated in human myeloid leukaemia HL-60. Indomethacin and nordihydroguaiaretic acid synergistically potentiated TNF-a induced apoptosis. Our data raise the possibility that indomethacin could potentially be used to improve the treatment of human myeloid leukaemia. (en)
Title
  • Inhibitors of arachidonic acid metabolism potentiate tumor necrosis factor-alfa-induced apoptosis in HL-60 cells
  • Inhibitors of arachidonic acid metabolism potentiate tumor necrosis factor-alfa-induced apoptosis in HL-60 cells (en)
skos:prefLabel
  • Inhibitors of arachidonic acid metabolism potentiate tumor necrosis factor-alfa-induced apoptosis in HL-60 cells
  • Inhibitors of arachidonic acid metabolism potentiate tumor necrosis factor-alfa-induced apoptosis in HL-60 cells (en)
skos:notation
  • RIV/00027162:_____/01:80000065!RIV/2002/MZE/M03002/N
http://linked.open.../vavai/riv/strany
  • 1;11
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZE-M03-99-01)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 683020
http://linked.open...ai/riv/idVysledku
  • RIV/00027162:_____/01:80000065
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Retinoic acid; all-trans; TNF-alfa (tumor necrosis factor-alfa); Fas; Arachidonic acid; Lipoxygenase; Cyclooxygenase; PPAR (Peroxisome proliferator-activated receptor) (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [B2C59F92BEFE]
http://linked.open...i/riv/nazevZdroje
  • European Journal Pharmacology
http://linked.open...in/vavai/riv/obor
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 424
http://linked.open...iv/tvurceVysledku
  • Vondráček, Jan
http://linked.open...n/vavai/riv/zamer
issn
  • 0014-2999
number of pages
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