About: Hydrophobically modified celluloses as novel cholesterol-lowering polymers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.vuzv.cz/sites/File/_privat/14056.pdf
Description	Hydrophobically modified celluloses were prepared by the esterification of monocarboxycellulose (MCC) and carboxymethylcellulose (CMC) with methanol, followed by the amino-de-alkoxylation of the methyl esters with n-octadecylamine. These cellulose derivatives were fed at 30 and 60 g/kg for 4 weeks to female rats. The diets were supplemented with palm fat (60 or 50 g/kg) and cholesterol (0 or 10 g/kg). There was no significant effect of amidated celluloses on the feed intake or body weight of rats. Both MCC and CMC derivatives significantly decreased the concentrations of cholesterol present in the serum and liver. The supplementation of diets with hydrophobically modified celluloses tended to increase fecal concentrations of cholesterol and coprostanol and significantly increased fecal concentrations of total neutral sterols. In rats fed diets containing cholesterol, the total serum cholesterol correlated negatively with the fecal concentrations of neutral sterols. It can be concluded that MCC-C18 and CMC-C18 are effective cholesterol-lowering agents. Hydrophobically modified celluloses were prepared by the esterification of monocarboxycellulose (MCC) and carboxymethylcellulose (CMC) with methanol, followed by the amino-de-alkoxylation of the methyl esters with n-octadecylamine. These cellulose derivatives were fed at 30 and 60 g/kg for 4 weeks to female rats. The diets were supplemented with palm fat (60 or 50 g/kg) and cholesterol (0 or 10 g/kg). There was no significant effect of amidated celluloses on the feed intake or body weight of rats. Both MCC and CMC derivatives significantly decreased the concentrations of cholesterol present in the serum and liver. The supplementation of diets with hydrophobically modified celluloses tended to increase fecal concentrations of cholesterol and coprostanol and significantly increased fecal concentrations of total neutral sterols. In rats fed diets containing cholesterol, the total serum cholesterol correlated negatively with the fecal concentrations of neutral sterols. It can be concluded that MCC-C18 and CMC-C18 are effective cholesterol-lowering agents. (en)
Title	Hydrophobically modified celluloses as novel cholesterol-lowering polymers Hydrophobically modified celluloses as novel cholesterol-lowering polymers (en)
skos:prefLabel	Hydrophobically modified celluloses as novel cholesterol-lowering polymers Hydrophobically modified celluloses as novel cholesterol-lowering polymers (en)
skos:notation	RIV/00027014:_____/14:#0002011!RIV15-MZE-00027014
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP503/11/2479), Z(MZE0002701404)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Volek, Zdeněk Marounek, Milan Dušková, Dagmar
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav živočišné výroby, v.v.i.
http://linked.open...dnocenehoVysledku	20122
http://linked.open...ai/riv/idVysledku	RIV/00027014:_____/14:#0002011
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Modified celluloses, Dietary sorbents, Cholesterol, Neutral sterols, Rats (en)
http://linked.open.../riv/klicoveSlovo	Cholesterol Rats Dietary sorbents Modified celluloses Neutral sterols
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D727043DF5F1]
http://linked.open...i/riv/nazevZdroje	BioResources
http://linked.open...in/vavai/riv/obor	GH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Inhibition of intestinal absorption of sterols by hydrophobically modified polysaccharides
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Dušková, Dagmar Marounek, Milan Synytsya, Andriy Tůma, Jan Volek, Zdeněk
http://linked.open...ain/vavai/riv/wos	000344184300043
http://linked.open...n/vavai/riv/zamer	Udržitelný rozvoj chovu hospodářských zvířat v evropském modelu multifunkčního zemědělství
issn	1930-2126
number of pages	8 (xsd:int)

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