About: Dose–response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats

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About: Dose–response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.vuzv.cz/sites/File/_privat/13088.pdf
Description	The dose–response efficiency and long-term effect of the hypocholesterolemic effect of octadecylpectinamide was examined in female rats fed diets containing cholesterol at 10 g/kg. In our first experiment, amidated pectin supplied at 20 g/kg, 40 g/kg and 60 g/kg significantly decreased serum cholesterol from 3,32 mol/ml (control) to 1,23 mol/ml in a dose-dependent manner. In a second experiment, the hypocholesterolemic effect of amidated pectin supplied at 20 g/kg persisted after 3 months of feeding. In both experiments, the amidated pectin significantly decreased the concentrations of cholesterol in hepatic tissue and triacylglycerols in serum. The serum concentration of aspartate aminotransferase significantly increased in rats fed amidated pectin at 60 g/kg for 4 weeks, and at 20 g/kg for 3 months. In onclusion, amidated pectin at a low dose and used for a period shorter than 3 months might be considered as an effective hypocholesterolemic and lipid-lowering agent that may substitute typical antilipidemic drugs. The dose–response efficiency and long-term effect of the hypocholesterolemic effect of octadecylpectinamide was examined in female rats fed diets containing cholesterol at 10 g/kg. In our first experiment, amidated pectin supplied at 20 g/kg, 40 g/kg and 60 g/kg significantly decreased serum cholesterol from 3,32 mol/ml (control) to 1,23 mol/ml in a dose-dependent manner. In a second experiment, the hypocholesterolemic effect of amidated pectin supplied at 20 g/kg persisted after 3 months of feeding. In both experiments, the amidated pectin significantly decreased the concentrations of cholesterol in hepatic tissue and triacylglycerols in serum. The serum concentration of aspartate aminotransferase significantly increased in rats fed amidated pectin at 60 g/kg for 4 weeks, and at 20 g/kg for 3 months. In onclusion, amidated pectin at a low dose and used for a period shorter than 3 months might be considered as an effective hypocholesterolemic and lipid-lowering agent that may substitute typical antilipidemic drugs. (en)
Title	Dose–response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats Dose–response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats (en)
skos:prefLabel	Dose–response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats Dose–response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats (en)
skos:notation	RIV/00027014:_____/13:#0001857!RIV14-GA0-00027014
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP503/11/2479)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Volek, Zdeněk Marounek, Milan Dušková, Dagmar
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav živočišné výroby, v.v.i.
http://linked.open...dnocenehoVysledku	70476
http://linked.open...ai/riv/idVysledku	RIV/00027014:_____/13:#0001857
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Amidated pectin, Cholesterol, Rats, Serum, Liver (en)
http://linked.open.../riv/klicoveSlovo	Liver Amidated pectin Cholesterol Rats Serum
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[671142E3E6F5]
http://linked.open...i/riv/nazevZdroje	Carbohydrate Polymers
http://linked.open...in/vavai/riv/obor	GH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Inhibition of intestinal absorption of sterols by hydrophobically modified polysaccharides
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	97
http://linked.open...iv/tvurceVysledku	Dušková, Dagmar Marounek, Milan Tůma, Jan Volek, Zdeněk Taubner, Tomáš
http://linked.open...ain/vavai/riv/wos	000323805000072
issn	0144-8617
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.carbpol.2013.05.044

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