About: Variation in Ano-Genital Distance in Spontaneously Cycling Female Mice

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.vuzv.cz/sites/File/_privat/12145.pdf
Description	A recently observed developmental instability of the anogenital distance (AGD) in female mice indicates that natural prenatal androgens do not have such a robust effect on female genital morphology as has been generally assumed. Part of this instability might be caused by oestrous cyclicity. To check this assumption, we examined the effect of the stage of the oestrous cycle on the AGD in adult (61–75 days old) female mice. Consistent with our assumption, the female AGD (1) varied during the oestrous cycle (p < 0.05), indicating thus rapid changes in morphology of female external genitalia, and (2) showed good repeatability (>0.66) in each stage of the oestrous cycle, suggesting that female genital morphology systematically varied within the oestrous cycle. Therefore, the stage of the oestrous cycle should be considered when assessing prenatal masculinization in adult female mice. A recently observed developmental instability of the anogenital distance (AGD) in female mice indicates that natural prenatal androgens do not have such a robust effect on female genital morphology as has been generally assumed. Part of this instability might be caused by oestrous cyclicity. To check this assumption, we examined the effect of the stage of the oestrous cycle on the AGD in adult (61–75 days old) female mice. Consistent with our assumption, the female AGD (1) varied during the oestrous cycle (p < 0.05), indicating thus rapid changes in morphology of female external genitalia, and (2) showed good repeatability (>0.66) in each stage of the oestrous cycle, suggesting that female genital morphology systematically varied within the oestrous cycle. Therefore, the stage of the oestrous cycle should be considered when assessing prenatal masculinization in adult female mice. (en)
Title	Variation in Ano-Genital Distance in Spontaneously Cycling Female Mice Variation in Ano-Genital Distance in Spontaneously Cycling Female Mice (en)
skos:prefLabel	Variation in Ano-Genital Distance in Spontaneously Cycling Female Mice Variation in Ano-Genital Distance in Spontaneously Cycling Female Mice (en)
skos:notation	RIV/00027014:_____/12:#0001700!RIV13-MZE-00027014
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZE0002701404)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Bartoš, Luděk Dušek, Adam
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Výzkumný ústav živočišné výroby, v.v.i.
http://linked.open...dnocenehoVysledku	177028
http://linked.open...ai/riv/idVysledku	RIV/00027014:_____/12:#0001700
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Genital morphology, Estrous cyclicity, Sex steroids, Sexual differentiation, Prenatal masculinization, Mouse, Rat, Rodents (en)
http://linked.open.../riv/klicoveSlovo	Rodents Rat Estrous cyclicity Genital morphology Prenatal masculinization Sex steroids Sexual differentiation Mouse
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[C3B702C3AC4C]
http://linked.open...i/riv/nazevZdroje	Reproduction in Domestic Animals
http://linked.open...in/vavai/riv/obor	EG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Bartoš, Luděk Dušek, Adam
http://linked.open...ain/vavai/riv/wos	000310790800021
http://linked.open...n/vavai/riv/zamer	Udržitelný rozvoj chovu hospodářských zvířat v evropském modelu multifunkčního zemědělství
issn	0936-6768
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1439-0531.2012.02003.x

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