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| rdf:type
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| Description
| - Embryonic stem cells (ES cells) represent a population of pluripotent, undifferentiated cells derived from early embryos that are capable of proliferating without any limitation in an undifferentiated state, and when injected into blastocysts, they can participate in the formation of all tissues. It is possible to transfect them with a gene of interest, and the resulting transgenic cell lines can also be used for production of chimeras. Before application of stem cell therapies into a human medicine, it is necessary to verify these methods with an acceptable animal model. The pig is currently used for pre-clinical applications, and therefore establishment of porcine ES cell lines is highly needed; unfortunately, no convincing ES cell lines have been produced in this species (and other domestic animals) to date. We discuss the recent advances in this field, especially oriented on possible reasons and obstacles why derivation of porcine ES cell lines is still unsuccessful.
- Embryonic stem cells (ES cells) represent a population of pluripotent, undifferentiated cells derived from early embryos that are capable of proliferating without any limitation in an undifferentiated state, and when injected into blastocysts, they can participate in the formation of all tissues. It is possible to transfect them with a gene of interest, and the resulting transgenic cell lines can also be used for production of chimeras. Before application of stem cell therapies into a human medicine, it is necessary to verify these methods with an acceptable animal model. The pig is currently used for pre-clinical applications, and therefore establishment of porcine ES cell lines is highly needed; unfortunately, no convincing ES cell lines have been produced in this species (and other domestic animals) to date. We discuss the recent advances in this field, especially oriented on possible reasons and obstacles why derivation of porcine ES cell lines is still unsuccessful. (en)
- Embryonální kmenové buňky (ES buňky) reprezentují populaci pluripotentních, nediferencovaných buněk odvozených z raných embryí, které jsou schopny neomezeného množení v nediferencovaném stavu. Pokud jsou vpraveny do blastocysty, mohou se podílet na vytváření všech typů tkání. Je možné je transfektovat příslušným genem; výsledné transgenní buněčné linie lze využít k tvorbě chimér. Před aplikací buněčných terapií kmenovými buňkami do humánní medicíny je třeba ověřit tyto metody pomocí vhodného zvířecího modelu. Prase je běžně používáno pro preklinické studie, a proto je velmi žádoucí ustavit prasečí ES buňky. Bohužel linie ES buněk nebyly u tohoto druhu (ani u ostatních domácích zvířat) doposud vytvořeny. Diskutujeme současné pokroky v tomto oboru, speciálně ty, které jsou zaměřeny na příčiny, proč je odvozování linií prasečích ES buněk dosud neúspěšné. (cs)
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| Title
| - Putative embryonic stem cell lines from pig embryos
- Putativní linie embryonálních kmenových buněk z prasečích embryí (cs)
- Putative embryonic stem cell lines from pig embryos (en)
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| skos:prefLabel
| - Putative embryonic stem cell lines from pig embryos
- Putativní linie embryonálních kmenových buněk z prasečích embryí (cs)
- Putative embryonic stem cell lines from pig embryos (en)
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| skos:notation
| - RIV/00027014:_____/07:#0000539!RIV08-MZE-00027014
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027014:_____/07:#0000539
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - chimera; embryonic stem cells; porcine (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Reproduction and Development
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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