About: Volumetric analysis of the pons, cerebellum and hippocampi in patients with Alzheimer´s disease     Goto   Sponge   NotDistinct   Permalink

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  • Background/Aims: Our goal was to find out whether a decrease in hippocampal volume in Alzheimer's disease measured via magnetic resonance imaging is accompanied by a similar volume decrease in the pons and cerebellum. We also tried to evaluate whether there are any accompanying hippocampal, pontine and cerebellar asymmetries between the left and right side. Methods: We performed a manual volumetric magnetic resonance analysis of the pons, cerebellum and hippocampi in 29 healthy controls and 26 patients with Alzheimer's disease, divided into two groups according to the Mini-Mental State Examination score. Results: We confirmed a known decrease in hippocampal volume in Alzheimer's disease patients but found that there is no similar volume decrease in the pons or cerebellum that could serve as a radiologic diagnostic tool in Alzheimer's disease diagnosis. Also, there was no statistically significant right-left asymmetry in all three measured structures. Conclusion: Only hippocampal volume and not pontine and cerebellar volumes could serve as a magnetic resonance diagnostic tool in Alzheimer's disease.
  • Background/Aims: Our goal was to find out whether a decrease in hippocampal volume in Alzheimer's disease measured via magnetic resonance imaging is accompanied by a similar volume decrease in the pons and cerebellum. We also tried to evaluate whether there are any accompanying hippocampal, pontine and cerebellar asymmetries between the left and right side. Methods: We performed a manual volumetric magnetic resonance analysis of the pons, cerebellum and hippocampi in 29 healthy controls and 26 patients with Alzheimer's disease, divided into two groups according to the Mini-Mental State Examination score. Results: We confirmed a known decrease in hippocampal volume in Alzheimer's disease patients but found that there is no similar volume decrease in the pons or cerebellum that could serve as a radiologic diagnostic tool in Alzheimer's disease diagnosis. Also, there was no statistically significant right-left asymmetry in all three measured structures. Conclusion: Only hippocampal volume and not pontine and cerebellar volumes could serve as a magnetic resonance diagnostic tool in Alzheimer's disease. (en)
Title
  • Volumetric analysis of the pons, cerebellum and hippocampi in patients with Alzheimer´s disease
  • Volumetric analysis of the pons, cerebellum and hippocampi in patients with Alzheimer´s disease (en)
skos:prefLabel
  • Volumetric analysis of the pons, cerebellum and hippocampi in patients with Alzheimer´s disease
  • Volumetric analysis of the pons, cerebellum and hippocampi in patients with Alzheimer´s disease (en)
skos:notation
  • RIV/00023752:_____/12:43913816!RIV13-MZ0-00023752
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GBP304/12/G069), P(NT13183), S, V
http://linked.open...iv/cisloPeriodika
  • 3-4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 178562
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  • RIV/00023752:_____/12:43913816
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  • asymmetry; volumetry; Alzheimer´s disease; pons; cerebellum; hippocampus (en)
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  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [D14AE4A4D8B8]
http://linked.open...i/riv/nazevZdroje
  • Dementia and Geriatric Cognitive Disorders
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
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  • 34
http://linked.open...iv/tvurceVysledku
  • Bartoš, Aleš
  • Řípová, Daniela
  • Zach, Petr
  • Tintěra, Jaroslav
  • Mrzilková, Jana
http://linked.open...ain/vavai/riv/wos
  • 000312897800011
issn
  • 1420-8008
number of pages
http://bibframe.org/vocab/doi
  • 10.1159/000343445
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