About: Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament

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About: Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.jneuroim.2012.08.001
Description	The role of humoral immunity related to neuron- and disease-specific cytoskeletal proteins patients with Alzheimer disease (AD) is unknown. We measured antibodies against tau protein, light and heavy (NFH) neurofilaments using ELISA in 80 paired serum and cerebrospinal fluid (CSF) samples from patients with AD, with other dementias (OD), with neuro-inflammatory diseases (IC) and 25 controls (NC). We estimated intrathecal synthesis according to the formula (CSF/serum anti-neurocytoskeletal IgG)/(CSF/serum total IgG). AD patients had significantly higher intrathecal anti-tau and anti-NFH antibodies than the other groups. These innovative findings may hint at specific alterations in humoral anti-neurocytoskeletal immunity and selectivity in AD, which could have diagnostic and immunotherapeutic implications. The role of humoral immunity related to neuron- and disease-specific cytoskeletal proteins patients with Alzheimer disease (AD) is unknown. We measured antibodies against tau protein, light and heavy (NFH) neurofilaments using ELISA in 80 paired serum and cerebrospinal fluid (CSF) samples from patients with AD, with other dementias (OD), with neuro-inflammatory diseases (IC) and 25 controls (NC). We estimated intrathecal synthesis according to the formula (CSF/serum anti-neurocytoskeletal IgG)/(CSF/serum total IgG). AD patients had significantly higher intrathecal anti-tau and anti-NFH antibodies than the other groups. These innovative findings may hint at specific alterations in humoral anti-neurocytoskeletal immunity and selectivity in AD, which could have diagnostic and immunotherapeutic implications. (en)
Title	Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament (en)
skos:prefLabel	Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament (en)
skos:notation	RIV/00023752:_____/12:43913790!RIV13-MZ0-00023752
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GBP304/12/G069), P(NT13183)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Řípová, Daniela Bartoš, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	157956
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/12:43913790
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neurofilament; tau protein; antibody; cerebrospinal fluid; serum; Alzheimer disease (en)
http://linked.open.../riv/klicoveSlovo	tau protein antibody neurofilament Alzheimer disease serum cerebrospinal fluid
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[FDA3D7F3BCFC]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroimmunology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Project of excellence in the field of neuroscience Brief psychometric instruments for early diagnosis of Alzheimer's disease in senior population
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	252
http://linked.open...iv/tvurceVysledku	Bartoš, Aleš Řípová, Daniela Švarcová, Jana Fialová, Lenka
http://linked.open...ain/vavai/riv/wos	000311132500013
issn	0165-5728
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jneuroim.2012.08.001

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