About: Impact of psychotropic drugs on adult hippocampal neurogenesis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.neures.2012.02.014
Description	This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation than the performance of cognitive tasks. In this review we provide some evidence for this assumption. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation than the performance of cognitive tasks. In this review we provide some evidence for this assumption. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. (en)
Title	Impact of psychotropic drugs on adult hippocampal neurogenesis Impact of psychotropic drugs on adult hippocampal neurogenesis (en)
skos:prefLabel	Impact of psychotropic drugs on adult hippocampal neurogenesis Impact of psychotropic drugs on adult hippocampal neurogenesis (en)
skos:notation	RIV/00023752:_____/12:43913772!RIV13-MZ0-00023752
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS10378)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Horáček, Jiří Páleníček, Tomáš Bubeníková-Valešová, Věra Kubešová, Anna Mertlová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	140680
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/12:43913772
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hippocampus; cognitive function; psychotropic drugs; adult neurogenesis (en)
http://linked.open.../riv/klicoveSlovo	hippocampus cognitive function psychotropic drugs adult neurogenesis
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[AEAF5AF1F69A]
http://linked.open...i/riv/nazevZdroje	Neuroscience Research
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Sex differences in the effect of 3,4-methylendioxametemphetamine (MDMA) on cognitive function, neurogenesis and farmacokinetics parameters
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Horáček, Jiří Páleníček, Tomáš Bubeníková-Valešová, Věra Kubešová, Anna Mertlová, Markéta
http://linked.open...ain/vavai/riv/wos	000304520200001
issn	0168-0102
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.neures.2012.02.014

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