About: Antidepressant monotherapy and combination of antidepressants in the treatment of resistant depression in current clinical practice. A retrospective study

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About: Antidepressant monotherapy and combination of antidepressants in the treatment of resistant depression in current clinical practice. A retrospective study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to compare efficacy of antidepressant monotherapies and combinations of antidepressants in the treatment of resistant patients in current clinical practice. We reviewed chart documents of resistant depressive inpatients treated at least 4 weeks with a new treatment. Depressive symptoms and clinical status were assessed using Montgomery and Åsberg Depression Rating Scale (MADRS), Beck Depression Inventory?Short Form and Clinical Global Impression at the baseline, week 2 and in the end of treatment. We identified 81 patients (27 with combinations and 51 with monotherapies) that were suitable for analyses. The combination group achieved higher reduction of MADRS score (14.6 vs 10.2 pts., p=0.02) and response rate (>= 50% reduction of MADRS, 67% vs 39%, p=0.03). Number needed to treat for response was 4. Based on our results, we suggest that combination of antidepressants might be more effective than monotherapy in clinical practice. The aim of this study was to compare efficacy of antidepressant monotherapies and combinations of antidepressants in the treatment of resistant patients in current clinical practice. We reviewed chart documents of resistant depressive inpatients treated at least 4 weeks with a new treatment. Depressive symptoms and clinical status were assessed using Montgomery and Åsberg Depression Rating Scale (MADRS), Beck Depression Inventory?Short Form and Clinical Global Impression at the baseline, week 2 and in the end of treatment. We identified 81 patients (27 with combinations and 51 with monotherapies) that were suitable for analyses. The combination group achieved higher reduction of MADRS score (14.6 vs 10.2 pts., p=0.02) and response rate (>= 50% reduction of MADRS, 67% vs 39%, p=0.03). Number needed to treat for response was 4. Based on our results, we suggest that combination of antidepressants might be more effective than monotherapy in clinical practice. (en)
Title	Antidepressant monotherapy and combination of antidepressants in the treatment of resistant depression in current clinical practice. A retrospective study Antidepressant monotherapy and combination of antidepressants in the treatment of resistant depression in current clinical practice. A retrospective study (en)
skos:prefLabel	Antidepressant monotherapy and combination of antidepressants in the treatment of resistant depression in current clinical practice. A retrospective study Antidepressant monotherapy and combination of antidepressants in the treatment of resistant depression in current clinical practice. A retrospective study (en)
skos:notation	RIV/00023752:_____/10:00001073!RIV11-MZ0-00023752
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(NS10368), V, Z(MZ0PCP2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Höschl, Cyril Kopeček, Miloslav Bareš, Martin Novák, Tomáš Stopková, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	247097
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/10:00001073
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	resistant depression; antidepressant monotherapy; combinations of antidepressants (en)
http://linked.open.../riv/klicoveSlovo	antidepressant monotherapy combinations of antidepressants resistant depression
http://linked.open...odStatuVydavatele	NO - Norské království
http://linked.open...ontrolniKodProRIV	[9849E142A85A]
http://linked.open...i/riv/nazevZdroje	International Journal of Psychiatry in Clinical Practice
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Prospective, randomized evaluation of efficacy of antidepressant monotherapy and antidepressant combination in the treatment of patients with resistant depression.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Bareš, Martin Höschl, Cyril Kopeček, Miloslav Novák, Tomáš Stopková, Pavla
http://linked.open...ain/vavai/riv/wos	000282811500013
http://linked.open...n/vavai/riv/zamer	Study of Sources f Psychiatric Morbidity , and Increasing the Effec-tiveness of the Preventative and Therapeutical methods in mental Health Care in the Czech Republic 2005?2011
issn	1365-1501
number of pages	6 (xsd:int)

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