About: Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to describe sex differences in the behavioural effects of N,N-diethyllysergamide (LSD) (locomotor activity and other behavioural repertoire in the open field) and its effects on sensorimotor gating in rats (prepulse inhibition (PPI) of the acoustic startle reaction). Three groups of animals were analysed: males, oestral and pro-oestral phase females (EP females), and metoestral and dioestral phase females (MD females). LSD (5, 50 and 200 μg/kg subcutaneously) attenuated locomotor activity and normal behavioural repertoire, and induced flat body posture, wet dog shakes and disrupted PPI. The most prominent behavioural findings of LSD were for LSD 200 μg/kg which suppressed almost all behavioural activity. LSD had mainly inhibitory locomotor effects in males and MD females, yet in EP female rats LSD increased locomotion during the second half of testing period. The main sex differences were observed in locomotor and exploratory behaviour. Both EP and MD females were The aim of this study was to describe sex differences in the behavioural effects of N,N-diethyllysergamide (LSD) (locomotor activity and other behavioural repertoire in the open field) and its effects on sensorimotor gating in rats (prepulse inhibition (PPI) of the acoustic startle reaction). Three groups of animals were analysed: males, oestral and pro-oestral phase females (EP females), and metoestral and dioestral phase females (MD females). LSD (5, 50 and 200 μg/kg subcutaneously) attenuated locomotor activity and normal behavioural repertoire, and induced flat body posture, wet dog shakes and disrupted PPI. The most prominent behavioural findings of LSD were for LSD 200 μg/kg which suppressed almost all behavioural activity. LSD had mainly inhibitory locomotor effects in males and MD females, yet in EP female rats LSD increased locomotion during the second half of testing period. The main sex differences were observed in locomotor and exploratory behaviour. Both EP and MD females were (en)
Title	Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition (en)
skos:prefLabel	Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition (en)
skos:notation	RIV/00023752:_____/10:00001054!RIV11-MZ0-00023752
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(NR9324), P(NS10374), P(NS10375), Z(MZ0PCP2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Horáček, Jiří Páleníček, Tomáš Bubeníková-Valešová, Věra Novák, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	287110
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/10:00001054
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N,N-diethyllysergamide (LSD); locomotion; open field; prepulse inhibition; rats; sex differences (en)
http://linked.open.../riv/klicoveSlovo	locomotion N sex differences rats open field prepulse inhibition N-diethyllysergamide (LSD)
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[AE38B8C3C078]
http://linked.open...i/riv/nazevZdroje	Progress in Neuro-Psychopharmacology & Biological Psychiatry
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of serotonin and noradrenaline reuptake inhibitors as potential antidotes for intoxications with dangerous synthetic drugs 2C-B and DOB – pharmacokinetics, behavioral and QEEG effects Role of metabotropic mGlu2/3 a AMPA glutamatergic receptors in neurobiology of schizophrenia Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) The candidate genes for schizophrenia: the influence on phenotypic variability in patients and in vitro manipulation of gene expression by the use of siRNA.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	34
http://linked.open...iv/tvurceVysledku	Horáček, Jiří Novák, Tomáš Páleníček, Tomáš Bubeníková-Valešová, Věra Hliňák, Zdeněk
http://linked.open...ain/vavai/riv/wos	000278885700003
http://linked.open...n/vavai/riv/zamer	Study of Sources f Psychiatric Morbidity , and Increasing the Effec-tiveness of the Preventative and Therapeutical methods in mental Health Care in the Czech Republic 2005?2011
issn	0278-5846
number of pages	9 (xsd:int)

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