About: Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect

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About: Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background. Theta cordance is a novel quantitative electroencephalography (QEEG) measure that correlates with cerebral perfusion. A series of clinical studies has demonstrated that the prefrontal theta cordance value decreases after 1 week of treatment in responders to antidepressants and that this effect precedes clinical improvement. Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown. Method. In a double-blind, cross-over, placebo-controlled experiment we studied the acute effect of ketamine (0.54 mg/kg within 30 min) on theta cordance in a group of 20 healthy volunteers. Results. Ketamine infusion induced a decrease in prefrontal theta cordance and an increase in the central region theta cordance after 10 and 30 min. The change in prefrontal theta cordance correlated with ketamine and norketamine blood levels after 10 min of ketamine infusion. Conclusions. Our data indicate that Background. Theta cordance is a novel quantitative electroencephalography (QEEG) measure that correlates with cerebral perfusion. A series of clinical studies has demonstrated that the prefrontal theta cordance value decreases after 1 week of treatment in responders to antidepressants and that this effect precedes clinical improvement. Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown. Method. In a double-blind, cross-over, placebo-controlled experiment we studied the acute effect of ketamine (0.54 mg/kg within 30 min) on theta cordance in a group of 20 healthy volunteers. Results. Ketamine infusion induced a decrease in prefrontal theta cordance and an increase in the central region theta cordance after 10 and 30 min. The change in prefrontal theta cordance correlated with ketamine and norketamine blood levels after 10 min of ketamine infusion. Conclusions. Our data indicate that (en)
Title	Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect (en)
skos:prefLabel	Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect (en)
skos:notation	RIV/00023752:_____/10:00001049!RIV11-MZ0-00023752
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0517), P(NR8792), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Höschl, Cyril Kopřivová, Jana Brunovský, Martin Horáček, Jiří Páleníček, Tomáš Kohútová, Barbora Bubeníková-Valešová, Věra Mohr, Pavel Novák, Tomáš Španiel, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	290914
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/10:00001049
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Depression; healthy volunteers; ketamine; QEEG; theta cordance (en)
http://linked.open.../riv/klicoveSlovo	Depression healthy volunteers ketamine QEEG theta cordance
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CE7A366DE1AD]
http://linked.open...i/riv/nazevZdroje	Psychological Medicine
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Glutamatergic theory of schizophrenia in animal and human models of disconnection tested by comparison with a population of schizophrenic patients Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Brunovský, Martin Horáček, Jiří Höschl, Cyril Kopřivová, Jana Mohr, Pavel Novák, Tomáš Páleníček, Tomáš Bubeníková-Valešová, Věra Tišlerová, Barbora Španiel, Filip Balíková, M.
http://linked.open...ain/vavai/riv/wos	000281408500004
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0033-2917
number of pages	9 (xsd:int)

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