About: Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk study     Goto   Sponge   NotDistinct   Permalink

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  • Objective: Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD have yet been identified. To test whether amygdala or hippocampal volumes represent an endophenotype for BD, we measured mesiotemporal volumes in young affected and unaffected relatives of patients with BD (high-risk design). Method: High-risk participants (aged 15 to 30 years) were recruited from families multiply affected with BD. They included 20 affected and 26 unaffected offspring of parents with primary mood disorders, matched by age and sex with 31 control subjects without a personal or family history of psychiatric disorders. Amygdala and hippocampal volumes were measured on 1.5 Tesla 3-dimensional anatomical magnetic resonance images using standard methods. Results: We found comparable amygdala and hippocampal volumes among unaffected relatives, affected high-risk patients, and control subjects. The exclusion of 6 medicated patients did not change the results. There were no differences between participants with family history of BD 1, compared with participants with family history of BD 11, or between subjects with family history of BID with psychotic symptoms, compared with subjects with family history of BD without psychotic symptoms. Conclusions: Hippocampal and amygdala volume abnormalities were absent in unaffected and affected relatives of patients with BD and thus did not meet criteria for endophenotype.
  • Objective: Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD have yet been identified. To test whether amygdala or hippocampal volumes represent an endophenotype for BD, we measured mesiotemporal volumes in young affected and unaffected relatives of patients with BD (high-risk design). Method: High-risk participants (aged 15 to 30 years) were recruited from families multiply affected with BD. They included 20 affected and 26 unaffected offspring of parents with primary mood disorders, matched by age and sex with 31 control subjects without a personal or family history of psychiatric disorders. Amygdala and hippocampal volumes were measured on 1.5 Tesla 3-dimensional anatomical magnetic resonance images using standard methods. Results: We found comparable amygdala and hippocampal volumes among unaffected relatives, affected high-risk patients, and control subjects. The exclusion of 6 medicated patients did not change the results. There were no differences between participants with family history of BD 1, compared with participants with family history of BD 11, or between subjects with family history of BID with psychotic symptoms, compared with subjects with family history of BD without psychotic symptoms. Conclusions: Hippocampal and amygdala volume abnormalities were absent in unaffected and affected relatives of patients with BD and thus did not meet criteria for endophenotype. (en)
Title
  • Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk study
  • Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk study (en)
skos:prefLabel
  • Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk study
  • Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk study (en)
skos:notation
  • RIV/00023752:_____/09:43914555!RIV14-MZ0-00023752
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N, V
http://linked.open...iv/cisloPeriodika
  • 11
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 302667
http://linked.open...ai/riv/idVysledku
  • RIV/00023752:_____/09:43914555
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • high-risk; volumetry; magnetic resonance imaging; bipolar disorders; hippocampus; amygdala (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CA - Kanada
http://linked.open...ontrolniKodProRIV
  • [55A90789211F]
http://linked.open...i/riv/nazevZdroje
  • Canadian Journal of Psychiatry-Revue Canadienne de Psychiatrie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 54
http://linked.open...iv/tvurceVysledku
  • Alda, Martin
  • Hájek, Tomáš
  • Duffy, Anne
  • Gunde, Eva
  • MacQueen, Glenda
  • Propper, Lukas
  • Slaney, Claire
http://linked.open...ain/vavai/riv/wos
  • 000272058900005
issn
  • 0706-7437
number of pages
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