About: Lithium response across generations

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	OBJECTIVE: To describe and integrate observations from bipolar patients responsive to lithium stabilization and their children. METHOD: Selected findings are described from the clinical and biological investigations of adults meeting research criteria for bipolar disorder and for responsiveness to lithium stabilization; and from prospective studies of the children of lithium responders and non-responders. RESULTS: Response to prophylactic lithium identifies a valid subtype of bipolar disorder, however the search for biological markers of lithium response, while promising, has so far remained inconclusive. Adult responders to lithium stabilization exhibit definable clinical features which are also observable in their affected children. In prospective studies the children of bipolar parents develop symptoms earlier than reported previously, with marked differences between the offspring of lithium responders and non-responders. The illness evolves in predictable clinical stages, first from non-specific OBJECTIVE: To describe and integrate observations from bipolar patients responsive to lithium stabilization and their children. METHOD: Selected findings are described from the clinical and biological investigations of adults meeting research criteria for bipolar disorder and for responsiveness to lithium stabilization; and from prospective studies of the children of lithium responders and non-responders. RESULTS: Response to prophylactic lithium identifies a valid subtype of bipolar disorder, however the search for biological markers of lithium response, while promising, has so far remained inconclusive. Adult responders to lithium stabilization exhibit definable clinical features which are also observable in their affected children. In prospective studies the children of bipolar parents develop symptoms earlier than reported previously, with marked differences between the offspring of lithium responders and non-responders. The illness evolves in predictable clinical stages, first from non-specific (en)
Title	Lithium response across generations Lithium response across generations (en)
skos:prefLabel	Lithium response across generations Lithium response across generations (en)
skos:notation	RIV/00023752:_____/09:00001035!RIV10-MZ0-00023752
http://linked.open...avai/riv/aktivita	S V
http://linked.open...avai/riv/aktivity	S, V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hájek, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	323940
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/09:00001035
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bipolar disorders; offspring; children; lithium; long-term treatment; stabilization; clinical profile; responders; biological markers (en)
http://linked.open.../riv/klicoveSlovo	responders offspring long-term treatment children lithium stabilization biological markers bipolar disorders clinical profile
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[34644362A1EF]
http://linked.open...i/riv/nazevZdroje	Acta Psychiatrica Scandinavica
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	120
http://linked.open...iv/tvurceVysledku	Hájek, Tomáš Alda, M. Duffy, Anne Grof, Paul
http://linked.open...ain/vavai/riv/wos	000270586600007
issn	0001-690X
number of pages	8 (xsd:int)

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