About: Striatal volumes in affected and unaffected relatives of bipolar patients

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	BACKGROUND: Striatal volume changes reported in bipolar disorders could represent artifacts of medication or comorbid conditions, or illness related changes, either biological predispositions or consequences of illness burden. We conducted volumetric high-risk study to investigate whether striatal volume changes represent primary biological risk factor for bipolar disorders. METHODS: High-risk (HR) participants (age range 15-30 years) were recruited from families multiply affected with bipolar disorders. They included 20 affected and 26 unaffected offspring of parents with primary mood disorders, matched by age and sex with 31 controls without a personal or family history of psychiatric disorders. Striatal volumes were measured on 1.5T 3D anatomical MRI images using standard methods. RESULTS: There was a significant difference between groups (affected, unaffected HR and control subjects) in caudate volumes (F=3.50, DF=2; 74 and p=0.04) in absence of putamen volume changes. The caudate volumes were lar BACKGROUND: Striatal volume changes reported in bipolar disorders could represent artifacts of medication or comorbid conditions, or illness related changes, either biological predispositions or consequences of illness burden. We conducted volumetric high-risk study to investigate whether striatal volume changes represent primary biological risk factor for bipolar disorders. METHODS: High-risk (HR) participants (age range 15-30 years) were recruited from families multiply affected with bipolar disorders. They included 20 affected and 26 unaffected offspring of parents with primary mood disorders, matched by age and sex with 31 controls without a personal or family history of psychiatric disorders. Striatal volumes were measured on 1.5T 3D anatomical MRI images using standard methods. RESULTS: There was a significant difference between groups (affected, unaffected HR and control subjects) in caudate volumes (F=3.50, DF=2; 74 and p=0.04) in absence of putamen volume changes. The caudate volumes were lar (en)
Title	Striatal volumes in affected and unaffected relatives of bipolar patients - high-risk study Striatal volumes in affected and unaffected relatives of bipolar patients - high-risk study (en)
skos:prefLabel	Striatal volumes in affected and unaffected relatives of bipolar patients - high-risk study Striatal volumes in affected and unaffected relatives of bipolar patients - high-risk study (en)
skos:notation	RIV/00023752:_____/09:00000949!RIV10-MZ0-00023752
http://linked.open...avai/riv/aktivita	S V
http://linked.open...avai/riv/aktivity	S, V
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hájek, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	344078
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/09:00000949
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bipolar disorders; caudate; putamen (en)
http://linked.open.../riv/klicoveSlovo	caudate putamen bipolar disorders
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[577046576C10]
http://linked.open...i/riv/nazevZdroje	Journal of Psychiatric Research
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Hájek, Tomáš Alda, M. Duffy, Anne Gunde, Eva Propper, Lukáš MacQueen, Glenda Slaney, Claire
http://linked.open...ain/vavai/riv/wos	000265469100008
issn	0022-3956
number of pages	6 (xsd:int)

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