About: Trazodone improves the results of cognitive behaviour therapy of primary insomnia in non-depressed patients     Goto   Sponge   NotDistinct   Permalink

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  • OBJECTIVES: Cognitive behaviour therapy (CBT) of primary insomnia is frequently combined with various pharmacological treatments, including sedative antidepressants. The present study was undertaken to evaluate the clinical efficacy of CBT singly and combined with trazodone pharmacotherapy, for primary insomnia. DESIGN AND SETTING: Randomised, comparative clinical trial, at a single academic medical centre. METHODS: Twenty outpatients (15 women, 5 men) with chronic primary insomnia were randomly assigned to CBT or CBT +100mg trazodone and treated for 8 weeks. The treatment outcome was estimated by mean changes from baseline in self-reported clinical scales, sleep continuity data and sleep architecture parameters. RESULTS: All patients perceived significant subjective sleep improvements. Sleep latency significantly shortened (p=0.03), sleep efficiency increased (p=0.004) and the total sleep time was significantly prolonged (p=0.006) after the CBT treatment in both groups. Sleep architecture showed that
  • OBJECTIVES: Cognitive behaviour therapy (CBT) of primary insomnia is frequently combined with various pharmacological treatments, including sedative antidepressants. The present study was undertaken to evaluate the clinical efficacy of CBT singly and combined with trazodone pharmacotherapy, for primary insomnia. DESIGN AND SETTING: Randomised, comparative clinical trial, at a single academic medical centre. METHODS: Twenty outpatients (15 women, 5 men) with chronic primary insomnia were randomly assigned to CBT or CBT +100mg trazodone and treated for 8 weeks. The treatment outcome was estimated by mean changes from baseline in self-reported clinical scales, sleep continuity data and sleep architecture parameters. RESULTS: All patients perceived significant subjective sleep improvements. Sleep latency significantly shortened (p=0.03), sleep efficiency increased (p=0.004) and the total sleep time was significantly prolonged (p=0.006) after the CBT treatment in both groups. Sleep architecture showed that (en)
  • Cílem studie bylo objektivně zhodnotit výsledky léčby trazodonem ve skupině pacientů s diagnozou chronické insomnie léčených kognitivně-behaviorální terapií (KBT). Metodika. Do studie bylo zařazeno 20 pacientů s diagnozou Neorganická nespavost F 51.0.15 žen a 5 mužů. Nespavost trvala průměrně 9,4 let, průměrný věk pacientů byl 47,4 let. 10 pacientů bylo léčeno pouze KBT. 10 pacientů bylo léčeno současně trazodonem a KBT. Před a po léčebné periodě bylo provedeno polysomnografické vyšetření. Výsledky. V celé skupině pacientů se statisticky významně zlepšují tyto spánkové parametry: celková doba spánku (p<0,006), spánkovou latence (p<0,03), spánkovou efektivita (p<0,004). Ve skupině léčené KBR+trazodonem došlo k statisticky významnému zvýšení zastoupení stadia S3+4 nonREM (p<0,04). Závěr: Kombinace KBT+trazodon zvyšuje zastoupení pomalovlnného spánku. (cs)
Title
  • Trazodone improves the results of cognitive behaviour therapy of primary insomnia in non-depressed patients
  • Efektivita trazodonu a kognitivně-behaviorální terapie v indikaci chronické insomnie (cs)
  • Trazodone improves the results of cognitive behaviour therapy of primary insomnia in non-depressed patients (en)
skos:prefLabel
  • Trazodone improves the results of cognitive behaviour therapy of primary insomnia in non-depressed patients
  • Efektivita trazodonu a kognitivně-behaviorální terapie v indikaci chronické insomnie (cs)
  • Trazodone improves the results of cognitive behaviour therapy of primary insomnia in non-depressed patients (en)
skos:notation
  • RIV/00023752:_____/08:00000921!RIV09-MZ0-00023752
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021620816), Z(MZ0PCP2005)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 400567
http://linked.open...ai/riv/idVysledku
  • RIV/00023752:_____/08:00000921
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • primary insomnia; cognitive behaviour therapy; antidepressants; trazodone; polysomnography; treatment outcome (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SE - Švédské království
http://linked.open...ontrolniKodProRIV
  • [B2764F9B8A40]
http://linked.open...i/riv/nazevZdroje
  • Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 29
http://linked.open...iv/tvurceVysledku
  • Brunovský, Martin
  • Horáček, Jiří
  • Höschl, Cyril
  • Krajča, Vladimír
  • Šóš, Peter
  • Matoušek, Miloš
  • Závěšická, Lucie
http://linked.open...n/vavai/riv/zamer
issn
  • 0172-780X
number of pages
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