| Attributes | Values |
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| rdf:type
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| Description
| - Serotoninové (5-HT) receptory hrají klíčovou roli u psychózy, kognitivních funkcích a nálady přes ovlivnění neurotransmiterů, synaptické integrity a plasticity. Především genetické studie ukazují, že jedno-nukleotidový polymorfismus u 5-HT1A, 5-HT2A a 5-HT2C receptorů souvisí s psychotickými symptomy, kognitivním poškozením a odpovědí na léčbu u pacientů se schizofrenií. Data s animálních studií upozorňují na význačnou úlohu 5-HT receptorů v kognitivních úlohách přes ovlivnění dopaminergní, cholinergní, glutamátergní a GABAergní neurotransmise. Tento článek shrnuje výsledky a vývoj nových prokognitivních látek na základě základního i klinického výzkumu. (cs)
- Serotonin (5-HT) receptors have been suggested to play key roles in psychosis, cognition, and mood via influence on neurotransmitters, synaptic integrity, and neural plasticity. Specifically, genetic evidence indicates that 5-HT1A, 5-HT2A, and 5-HT2C receptor single-nucleotide polymorphisms (SNPs) are related to psychotic symptoms, cognitive disturbances, and treatment response in schizophrenia. Data from animal research suggest the role of 5-HT in cognition via its influence on dopaminergic, cholinergic, glutamatergic, and GABAergic function. This article provides up-to-date findings on the role of 5-HT receptors in endophenotypic variations in schizophrenia and the development of newer cognition-enhancing medications, based on basic science and clinical evidence.
- Serotonin (5-HT) receptors have been suggested to play key roles in psychosis, cognition, and mood via influence on neurotransmitters, synaptic integrity, and neural plasticity. Specifically, genetic evidence indicates that 5-HT1A, 5-HT2A, and 5-HT2C receptor single-nucleotide polymorphisms (SNPs) are related to psychotic symptoms, cognitive disturbances, and treatment response in schizophrenia. Data from animal research suggest the role of 5-HT in cognition via its influence on dopaminergic, cholinergic, glutamatergic, and GABAergic function. This article provides up-to-date findings on the role of 5-HT receptors in endophenotypic variations in schizophrenia and the development of newer cognition-enhancing medications, based on basic science and clinical evidence. (en)
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| Title
| - Serotonin1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics
- Serotonin1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics (en)
- Serotonin-1A receptory v patofyziologii schizofrenie: Vývoj nové terapie posilující kognitivní funkce (cs)
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| skos:prefLabel
| - Serotonin1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics
- Serotonin1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics (en)
- Serotonin-1A receptory v patofyziologii schizofrenie: Vývoj nové terapie posilující kognitivní funkce (cs)
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| skos:notation
| - RIV/00023752:_____/08:00000840!RIV09-MZ0-00023752
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| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1M0517), P(NR8792), P(NR9324)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00023752:_____/08:00000840
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - 5-HT1A; 5-HT receptors; cognition; schizophrenia; serotonin; translational research (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Horáček, Jiří
- Bubeníková-Valešová, Věra
- Sumiyoshi, T.
- Bert, B.
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| issn
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| number of pages
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