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| rdf:type
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| Description
| - Multifunční mitochondriální enzym 17beta-hydroxysteroidová dehydrogenáza typu 10 by mohl hrát roli ve vývoji Alzheimerovy nemoci svou vysokoafinitní vazbou k peptidům amyloidu beta a zvýšenou expresí. Testovali jsme specificitu změn v mRNA/enzymové expresi v pravém a levém hipokampu lidí. U nedementních nepsychotických kontrol jsme nalezli trend k pravo/levé lateralitě, stupeň asymetrie byl však vyšší u mRNA než u exprese enzymu. U Alzheimerovy nemoci a u schizofrenie jsme pozorovali naopak levo/pravou asymetrii, která byla způsobena výraznějším nárůstem v levé hemisféře. Naše výsledky potvrzují vyšší zranitelnost dominantní hemisféry k patologickým procesům. Zvýšená exprese enzymu by mohla být využita k rozlišení Alzheimerovy nemoci od multi-infarktové demence. (cs)
- Objective: The multifunctional mitochondrial enzyme 17 beta -hydroxysteroid dehydrogenase type 10 could play a role in the development of Alzheimer disease via its high-affinity binding to amyloid- peptides and its overexpression. Methods: We evaluated the specificity of alterations in mRNA/enzyme expression levels in human right and left hippocampi. Results: We observed a trend towards right/left laterality in nondemented nonpsychotic controls; however, the degree of asymmetry was higher for mRNA when compared to enzyme expression levels. In Alzheimer disease and schizophrenia, significant shifts to left/right asymmetry were found and the changes were associated with more marked increases in mRNA/enzyme expression in the left hemisphere. On the other hand, no alterations were observed in people with multi-infarct dementia. Conclusion: Our results support studies reporting an impairment of mitochondria in Alzheimer disease or schizophrenia and a higher vulnerability of the dominant hemisphere to path
- Objective: The multifunctional mitochondrial enzyme 17 beta -hydroxysteroid dehydrogenase type 10 could play a role in the development of Alzheimer disease via its high-affinity binding to amyloid- peptides and its overexpression. Methods: We evaluated the specificity of alterations in mRNA/enzyme expression levels in human right and left hippocampi. Results: We observed a trend towards right/left laterality in nondemented nonpsychotic controls; however, the degree of asymmetry was higher for mRNA when compared to enzyme expression levels. In Alzheimer disease and schizophrenia, significant shifts to left/right asymmetry were found and the changes were associated with more marked increases in mRNA/enzyme expression in the left hemisphere. On the other hand, no alterations were observed in people with multi-infarct dementia. Conclusion: Our results support studies reporting an impairment of mitochondria in Alzheimer disease or schizophrenia and a higher vulnerability of the dominant hemisphere to path (en)
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| Title
| - Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people
- Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people (en)
- Lateralizace 17beta-hydroxysteroidové dehydrogenázy typu 10 v hipokampech dementních a psychotických lidí (cs)
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| skos:prefLabel
| - Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people
- Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people (en)
- Lateralizace 17beta-hydroxysteroidové dehydrogenázy typu 10 v hipokampech dementních a psychotických lidí (cs)
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| skos:notation
| - RIV/00023752:_____/08:00000833!RIV09-MZ0-00023752
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023752:_____/08:00000833
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - amyloid-beta-binding protein; brain laterality; postmortem tissue; Alzheimer disease; schizophrenia; multi-infarct dementia (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - CH - Švýcarská konfederace
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Dementia and Geriatric Cognitive Disorders
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Zach, P.
- Řípová, Daniela
- Říčný, Jan
- Hořínek, A.
- Krištofiková, Zdena
- Hovorková, Petra
- Majer, E.
- Sellinger, P.
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| number of pages
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