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| Description
| - Rationale Mescaline is a nonselective serotonin receptor agonist. It has relatively delayed onset of action and prolonged duration. Mescaline attenuates various behavioral parameters in rats; however, no information is available about its pharmacokinetics in rats and its relation to the behavioral changes produced by the drug. Objectives The present study evaluates the spontaneous locomotor activity and sensorimotor gating in relation to mescaline concentrations in the serum and the brain of rats Materials and methods Behavioral changes induced by mescaline [10, 20, and 100 mg/kg subcutaneously (s.c.)] were evaluated in an open-field test and testing of the prepulse inhibition of acoustic startle reaction (PPI) 15 and 60 min after drug administration. The time disposition of mescaline 20 mg/kg s.c. in rat serum and brain homogenates was analyzed by gas chromatography-mass spectrometry. Results Mescaline produced significant inhibitory effects on locomotion in low doses and a biphasic effect with the h
- Rationale Mescaline is a nonselective serotonin receptor agonist. It has relatively delayed onset of action and prolonged duration. Mescaline attenuates various behavioral parameters in rats; however, no information is available about its pharmacokinetics in rats and its relation to the behavioral changes produced by the drug. Objectives The present study evaluates the spontaneous locomotor activity and sensorimotor gating in relation to mescaline concentrations in the serum and the brain of rats Materials and methods Behavioral changes induced by mescaline [10, 20, and 100 mg/kg subcutaneously (s.c.)] were evaluated in an open-field test and testing of the prepulse inhibition of acoustic startle reaction (PPI) 15 and 60 min after drug administration. The time disposition of mescaline 20 mg/kg s.c. in rat serum and brain homogenates was analyzed by gas chromatography-mass spectrometry. Results Mescaline produced significant inhibitory effects on locomotion in low doses and a biphasic effect with the h (en)
- Mezkalin je neselektivní agonista serotoninových receptorů. Má relativně zpožděný nástup účinku a prodloužené trvání účinku. Mezkalin mění různé projevy chování u potkanů, nicméně o jeho farmakokinetice ve vztahu k behaviorálním účinkům je pouze minimum informací. Cílem této studie bylo posoudit spontánní lokomoční aktivitu a vliv na senzorimotorické zpracování informací ve vztahu ke koncentracím mezkalinu v séru a v mozku potkanů. Behaviorální změny vyvolané mezkalinem (10, 20, a 100 mg/kg subkutánně - s.c.) byly posuzovány v testu otevřeného pole a v testu prepulzní inhibice (PPI) akustické úlekové reakce a to za 15 a 60 minut po aplikaci látky. Časový profil mezkalinu 20mg/kg s.c. v séru a v mozku potkana byl analyzován plynovou chromatografií s hmotnostní detekcí. Výsledky studie prokazují, že mezkalin má v malých dávkách signifikantní inhibiční účinky na lokomoci, ve vysokých dávkách má bifázický účinek. V testu PPI akustické úlekové reakce všechny dávky narušily PPI ovšem pouze za 60 minut po (cs)
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| Title
| - Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose
- Účinky mezkalinu na chování potkana a jeho časový profil v séru a mozkové tkáni po subkutánní aplikaci dávky (cs)
- Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose (en)
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| skos:prefLabel
| - Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose
- Účinky mezkalinu na chování potkana a jeho časový profil v séru a mozkové tkáni po subkutánní aplikaci dávky (cs)
- Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose (en)
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| skos:notation
| - RIV/00023752:_____/08:00000819!RIV09-MZ0-00023752
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M0517), P(NR8332), P(NR8785)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023752:_____/08:00000819
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - mescaline; locomotion; sensorimotor gating; rats; pharmacokinetics (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Horáček, Jiří
- Páleníček, Tomáš
- Bubeníková-Valešová, Věra
- Balíková, M.
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| issn
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| number of pages
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